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Effects of photobiomodulation (660 nm laser) on anthracycline extravasation: An experimental study

Karina Alexandra Batista da Silva Freitas ; Minicucci, Eliana Maria ; Valéria Flávia Batista da Silva ; Menozzi, Benedito Donizete ; Langoni, Hélio ; Popim, Regina Célia

Revista latino-americana de enfermagem, 2022, Vol.30, p.e3693-e3693 [Periódico revisado por pares]

Sao Paulo: Universidade de São Paulo-USP, Escola de Enfermagem de Ribeirão Preto - USP

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  • Título:
    Effects of photobiomodulation (660 nm laser) on anthracycline extravasation: An experimental study
  • Autor: Karina Alexandra Batista da Silva Freitas ; Minicucci, Eliana Maria ; Valéria Flávia Batista da Silva ; Menozzi, Benedito Donizete ; Langoni, Hélio ; Popim, Regina Célia
  • Assuntos: Chemotherapy ; Edema ; Light therapy ; Medical diagnosis ; NURSING ; Original ; Rodents ; Side effects ; Topical medication
  • É parte de: Revista latino-americana de enfermagem, 2022, Vol.30, p.e3693-e3693
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    ObjectType-Undefined-3
    Authors’ contribution: Study concept and design: Karina Alexandra Batista da Silva Freitas, Eliana Maria Minicucci, Hélio Langoni, Regina Célia Popim. Obtaining data: Karina Alexandra Batista da Silva Freitas, Eliana Maria Minicucci, Valéria Flávia Batista da Silva, Benedito Donizete Menozzi, Hélio Langoni, Regina Célia Popim. Data analysis and interpretation: Karina Alexandra Batista da Silva Freitas, Eliana Maria Minicucci, Valéria Flávia Batista da Silva, Benedito Donizete Menozzi, Hélio Langoni, Regina Célia Popim. Statistical analysis: Karina Alexandra Batista da Silva Freitas, Valéria Flávia Batista da Silva. Drafting the manuscript: Karina Alexandra Batista da Silva Freitas, Eliana Maria Minicucci, Valéria Flávia Batista da Silva, Benedito Donizete Menozzi, Regina Célia Popim. Critical review of the manuscript as to its relevant intellectual content: Karina Alexandra Batista da Silva Freitas, Eliana Maria Minicucci, Valéria Flávia Batista da Silva, Benedito Donizete Menozzi, Hélio Langoni, Regina Célia Popim. Others (Development of the experimental part of the laboratory research): Karina Alexandra Batista da Silva Freitas, Benedito Donizete Menozzi, Hélio Langoni. All authors approved the final version of the text.
    Associate Editor: Evelin Capellari Cárnio
    Conflict of interest: The authors have declared that there is no conflict of interest.
  • Descrição: Objective: to investigate the effect of using different agents (topical hyaluronidase, photobiomodulation, and the association of photobiomodulation with topical hyaluronidase) in preventing the formation of lesions caused by doxorubicin extravasation, as well as in the reduction of lesions formed by extravasation of this drug. Method: a quasi-experimental study conducted with 60 Wistar rats, randomized into four groups with 15 animals each. Group 1 (Control); Group 2 (Hyaluronidase); Group 3 (Photobiomodulation); and Group 4 (Hyaluronidase + Photobiomodulation). A wound was induced by applying 1 mg of doxorubicin to the subcutaneous tissue of the back of the animals. The concentration of topical hyaluronidase was 65 turbidity units/g and the energy employed was 1 joule of 100 mW red laser per square centimeter. With macroscopic evaluation every two days for 28 days, the following variables were observed: skin integrity, presence of blisters, hyperemia, exudate, bleeding, edema, crust, peeling and granulation tissue. Results: the animals from the groups subjected to photobiomodulation obtained better results in the assessment of the following variables: bleeding, hyperemia, exudate, intact skin and edema. Conclusion: it was evidenced that the association of photobiomodulation with topical hyaluronidase was effective in reducing the local effects and assisted in the wound healing process, and that PBM alone was able to prevent appearance of lesions.
  • Editor: Sao Paulo: Universidade de São Paulo-USP, Escola de Enfermagem de Ribeirão Preto - USP
  • Idioma: Inglês;Português;Espanhol
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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