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Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility

Peres, D. A. ; de Oliveira, C. A. ; da Costa, M. S. ; Tokunaga, V. K. ; Mota, J. P. ; Rosado, C. ; Consiglieri, V. O. ; Kaneko, T. M. ; Velasco, M. V. R. ; Baby, A. R.

Skin research and technology, 2016-08, Vol.22 (3), p.325-333 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility
Autor: Peres, D. A. ; de Oliveira, C. A. ; da Costa, M. S. ; Tokunaga, V. K. ; Mota, J. P. ; Rosado, C. ; Consiglieri, V. O. ; Kaneko, T. M. ; Velasco, M. V. R. ; Baby, A. R.
Assuntos: Absorption, Radiation - drug effects ; Adult ; Antioxidants - metabolism ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Drug Synergism ; ethylhexyl dimethyl PABA ; ethylhexyl methoxycinnamate ; Female ; Filtration - methods ; flavonoid ; Humans ; octocrylene ; photoprotection ; photostability ; Radiation-Protective Agents - administration & dosage ; Rutin - administration & dosage ; Skin - drug effects ; Skin - radiation effects ; Skin Absorption - drug effects ; Skin Absorption - physiology ; Skin Absorption - radiation effects ; Skin Physiological Phenomena - drug effects ; Skin Physiological Phenomena - radiation effects ; Sunscreening Agents - administration & dosage ; Ultraviolet Rays - adverse effects ; Water Loss, Insensible - drug effects ; Water Loss, Insensible - physiology ; Water Loss, Insensible - radiation effects
É parte de: Skin research and technology, 2016-08, Vol.22 (3), p.325-333
Notas: ArticleID:SRT12265
ark:/67375/WNG-L6L75FTV-X
São Paulo Research Foundation - No. 2008/57800-0; No. 2010/10739-5
National Council of Technological and Scientific Development
istex:8DBF8E6A4CB6A72931082B34729CFD13514B3B19
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
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Descrição: Background/purpose Ultraviolet (UV) radiation is responsible for sunburns, skin cancer, photoaging, and the production of reactive oxygen species (ROS). The awareness on preventing these deleterious effects made the use of anti‐UVB formulations an important part of population habits; however, despite the availability of several antioxidants capable of ROS scavenging, the pharmaceutical market lacks products associating UV filters with natural compounds of proven efficacy. Here, we investigated the effect of rutin, a flavonoid with antioxidant activity, associated with UVB filters in dermocosmetic preparations. Methods Formulations were assessed through its antioxidant activity, in vitro photoprotective effectiveness, photostability, and in vivo skin tolerance (hydration, transepidermal water loss, and erythema). Results Samples containing rutin were compatible with the human skin and presented a pronounced antioxidant potential, with scavenging activity values 75% higher than the ones containing only UVB filters. Although rutin could not prevent the sunscreens photodegradation post‐irradiation, the bioactive compound significantly increased the formulations critical wavelengths, showing a photoprotective gain, especially in the UVA range. Conclusion In conclusion, the absorption in the UVA range, coupled with ROS scavenging potential, proved the positive effect of rutin applied to anti‐UVB formulations, making this bioactive compound a promising candidate for photoprotection improvement.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês

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Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility

Peres, D. A. ; de Oliveira, C. A. ; da Costa, M. S. ; Tokunaga, V. K. ; Mota, J. P. ; Rosado, C. ; Consiglieri, V. O. ; Kaneko, T. M. ; Velasco, M. V. R. ; Baby, A. R.

England: Blackwell Publishing Ltd

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