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Modulation of respiratory sinus arrhythmia in rats with central pattern generator hardware

Nogaret, Alain ; Zhao, Le ; Moraes, Davi J.A. ; Paton, Julian F.R.

Journal of neuroscience methods, 2013-01, Vol.212 (1), p.124-132 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Modulation of respiratory sinus arrhythmia in rats with central pattern generator hardware
Autor: Nogaret, Alain ; Zhao, Le ; Moraes, Davi J.A. ; Paton, Julian F.R.
Assuntos: Animals ; Arrhythmia ; Arrhythmia, Sinus - physiopathology ; Arterial Pressure ; Blood pressure ; Brain stem ; Bötzinger system ; Carotid Sinus - innervation ; Central pattern generator ; Central Pattern Generators - cytology ; Central Pattern Generators - physiology ; Clinical trials ; EKG ; Electric Stimulation - instrumentation ; Electric Stimulation - methods ; Electrocardiography ; Heart ; Heart rate ; Heart Rate - physiology ; Nervous system ; Neurons - physiology ; Neurostimulation ; Oscillations ; phrenic nerve ; Phrenic Nerve - physiology ; Prosthetics ; Rats ; Respiration ; Respiratory Mechanics - physiology ; Respiratory sinus arrhythmia ; Silicon ; Silicon central pattern generator ; Sinus ; Synapses ; Time Factors ; Vagus nerve ; Vagus Nerve - physiology
É parte de: Journal of neuroscience methods, 2013-01, Vol.212 (1), p.124-132
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Descrição: ► We have built a central pattern generator (CPG) in silicon hardware. ► We have successfully modulated the cardio-respiratory system of rats with this CPG. ► The vagus nerve was stimulated in phase with respiration as breathing pace varies. ► Respiratory sinus arrhythmia was induced in each phase of the respiration cycle. ► RSA is strongest in the inspiratory phase, weaker in the late expiratory phase. We report on the modulation of respiratory sinus arrhythmia in rats with central pattern generator (CPG) hardware made of silicon neurons. The neurons are made to compete through mutually inhibitory synapses to provide timed electrical oscillations that stimulate the peripheral end of vagus nerve at specific points of the respiratory cycle: the inspiratory phase (φ1), the early expiratory phase (φ2) and the late expiratory phase (φ3). In this way the CPG hardware mimics the neuron populations in the brainstem which through connections with cardiac vagal motoneurones control respiratory sinus arrhythmia (RSA). Here, we time the output of the CPG hardware from the phrenic nerve activity recorded from rats while monitoring heart rate changes evoked by vagal nerve stimulation (derived from ECG) controlled by the CPG. This neuroelectric stimulation has the effect of reducing the heart rate and increasing the arterial pressure. The artificially induced RSA strongly depends on the timing of pulses within the breathing cycle. It is strongest when the vagus nerve is stimulated during the inspiratory phase (φ1) or the early expiratory phase (φ2) in which case the heart rate slows by 50% of the normal rate. Heart rate modulation is less when the same exact stimulus is applied during the late expiratory phase (φ3). These trials show that neurostimulation by CPG hardware can augment respiratory sinus arrhythmia. The CPG hardware technology opens a new line of therapeutic possibilities for prosthetic devices that restore RSA in patients where respiratory-cardiac coupling has been lost.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Modulation of respiratory sinus arrhythmia in rats with central pattern generator hardware

Nogaret, Alain ; Zhao, Le ; Moraes, Davi J.A. ; Paton, Julian F.R.

Netherlands: Elsevier B.V

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