Idioma:

Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

Skibola, Christine F. ; Berndt, Sonja I. ; Vijai, Joseph ; Conde, Lucia ; Wang, Zhaoming ; Yeager, Meredith ; de Bakker, Paul I.W. ; Birmann, Brenda M. ; Vajdic, Claire M. ; Foo, Jia-Nee ; Bracci, Paige M. ; Vermeulen, Roel C.H. ; Slager, Susan L. ; de Sanjose, Silvia ; Linet, Martha S. ; Salles, Gilles ; Lan, Qing ; Severi, Gianluca ; Hjalgrim, Henrik ; Lightfoot, Tracy ; Melbye, Mads ; Gu, Jian ; Ghesquières, Hervé ; Link, Brian K. ; Morton, Lindsay M. ; Holly, Elizabeth A. ; Smith, Alex ; Tinker, Lesley F. ; Teras, Lauren R. ; Kricker, Anne ; Becker, Nikolaus ; Zhang, Yawei ; Giles, Graham G. ; Vineis, Paolo ; Monnereau, Alain ; Bertrand, Kimberly A. ; Albanes, Demetrius ; Zeleniuch-Jacquotte, Anne ; Gabbas, Attilio ; Chung, Charles C. ; Burdett, Laurie ; Hutchinson, Amy ; Lawrence, Charles ; Montalvan, Rebecca ; Liang, Liming ; Huang, Jinyan ; Ma, Baoshan ; Liu, Jianjun ; Adami, Hans-Olov ; Glimelius, Bengt ; Ye, Yuanqing ; Nowakowski, Grzegorz S. ; Thompson, Carrie A. ; Habermann, Thomas M. ; Novak, Anne J. ; Liebow, Mark ; Witzig, Thomas E. ; Weiner, George J. ; Schenk, Maryjean ; Hartge, Patricia ; De Roos, Anneclaire J. ; Cozen, Wendy ; Zhi, Degui ; Akers, Nicholas K. ; Riby, Jacques ; Smith, Martyn T. ; Lacher, Mortimer ; Roman, Eve ; Kane, Eleanor ; Jackson, Rebecca D. ; North, Kari E. ; Diver, W. Ryan ; Turner, Jenny ; Armstrong, Bruce K. ; Benavente, Yolanda ; Boffetta, Paolo ; Foretova, Lenka ; Maynadie, Marc ; Staines, Anthony ; McKay, James ; Zheng, Tongzhang ; Holford, Theodore R. ; Chamosa, Saioa ; Kaaks, Rudolph ; Kelly, Rachel S. ; Ohlsson, Bodil ; Travis, Ruth C. ; Weiderpass, Elisabete ; Clavel, Jacqueline ; Giovannucci, Edward ; Kraft, Peter ; Mazza, Patrizio ; Cocco, Pierluigi ; Chiu, Brian C.H. ; Fraumeni, Joseph F. ; Offit, Kenneth ; Wu, Xifeng ; Cerhan, James R. ; Smedby, Karin E. ; Chanock, Stephen J.

American journal of human genetics, 2014-10, Vol.95 (4), p.462-471 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region
Autor: Skibola, Christine F. ; Berndt, Sonja I. ; Vijai, Joseph ; Conde, Lucia ; Wang, Zhaoming ; Yeager, Meredith ; de Bakker, Paul I.W. ; Birmann, Brenda M. ; Vajdic, Claire M. ; Foo, Jia-Nee ; Bracci, Paige M. ; Vermeulen, Roel C.H. ; Slager, Susan L. ; de Sanjose, Silvia ; Linet, Martha S. ; Salles, Gilles ; Lan, Qing ; Severi, Gianluca ; Hjalgrim, Henrik ; Lightfoot, Tracy ; Melbye, Mads ; Gu, Jian ; Ghesquières, Hervé ; Link, Brian K. ; Morton, Lindsay M. ; Holly, Elizabeth A. ; Smith, Alex ; Tinker, Lesley F. ; Teras, Lauren R. ; Kricker, Anne ; Becker, Nikolaus ; Zhang, Yawei ; Giles, Graham G. ; Vineis, Paolo ; Monnereau, Alain ; Bertrand, Kimberly A. ; Albanes, Demetrius ; Zeleniuch-Jacquotte, Anne ; Gabbas, Attilio ; Chung, Charles C. ; Burdett, Laurie ; Hutchinson, Amy ; Lawrence, Charles ; Montalvan, Rebecca ; Liang, Liming ; Huang, Jinyan ; Ma, Baoshan ; Liu, Jianjun ; Adami, Hans-Olov ; Glimelius, Bengt ; Ye, Yuanqing ; Nowakowski, Grzegorz S. ; Thompson, Carrie A. ; Habermann, Thomas M. ; Novak, Anne J. ; Liebow, Mark ; Witzig, Thomas E. ; Weiner, George J. ; Schenk, Maryjean ; Hartge, Patricia ; De Roos, Anneclaire J. ; Cozen, Wendy ; Zhi, Degui ; Akers, Nicholas K. ; Riby, Jacques ; Smith, Martyn T. ; Lacher, Mortimer ; Roman, Eve ; Kane, Eleanor ; Jackson, Rebecca D. ; North, Kari E. ; Diver, W. Ryan ; Turner, Jenny ; Armstrong, Bruce K. ; Benavente, Yolanda ; Boffetta, Paolo ; Foretova, Lenka ; Maynadie, Marc ; Staines, Anthony ; McKay, James ; Zheng, Tongzhang ; Holford, Theodore R. ; Chamosa, Saioa ; Kaaks, Rudolph ; Kelly, Rachel S. ; Ohlsson, Bodil ; Travis, Ruth C. ; Weiderpass, Elisabete ; Clavel, Jacqueline ; Giovannucci, Edward ; Kraft, Peter ; Mazza, Patrizio ; Cocco, Pierluigi ; Chiu, Brian C.H. ; Fraumeni, Joseph F. ; Offit, Kenneth ; Wu, Xifeng ; Cerhan, James R. ; Smedby, Karin E. ; Chanock, Stephen J.
Assuntos: Alleles ; Amino acids ; Antigens ; Basic Medicine ; Biomarkers, Tumor - genetics ; Case-Control Studies ; Chromosomes, Human - genetics ; Gene loci ; Genetic Predisposition to Disease ; Genetics ; Genome-Wide Association Study ; Genomics ; Haplotypes - genetics ; HLA Antigens - genetics ; Humans ; Leucocytes ; Lymphoma ; Lymphoma, Follicular - genetics ; Medical and Health Sciences ; Medical Genetics ; Medicin och hälsovetenskap ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; Polymorphism, Single Nucleotide - genetics
É parte de: American journal of human genetics, 2014-10, Vol.95 (4), p.462-471
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work
These authors contributed equally to this work in a supervisory role
Descrição: Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10−20) near CXCR5; 11q24.3 (rs4937362, p = 6.76 × 10−11) near ETS1; 3q28 (rs6444305, p = 1.10 × 10−10) in LPP; 18q21.33 (rs17749561, p = 8.28 × 10−10) near BCL2; and 8q24.21 (rs13254990, p = 1.06 × 10−8) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRβ1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 × 10−67 to 2.67 × 10−70). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 × 10−16) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 × 10−9). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.