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Ets-1 maintains IL-7 receptor expression in peripheral T cells

Grenningloh, Roland ; Tai, Tzong-Shyuan ; Frahm, Nicole ; Hongo, Tomoyuki C ; Chicoine, Adam T ; Brander, Christian ; Kaufmann, Daniel E ; Ho, I-Cheng

The Journal of immunology (1950), 2011-01, Vol.186 (2), p.969-976 [Periódico revisado por pares]

United States

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Título:
Ets-1 maintains IL-7 receptor expression in peripheral T cells
Autor: Grenningloh, Roland ; Tai, Tzong-Shyuan ; Frahm, Nicole ; Hongo, Tomoyuki C ; Chicoine, Adam T ; Brander, Christian ; Kaufmann, Daniel E ; Ho, I-Cheng
Assuntos: Animals ; Cells, Cultured ; Female ; HIV-1 - immunology ; Human immunodeficiency virus ; Humans ; Interleukin-7 - biosynthesis ; Interleukin-7 - genetics ; Interleukin-7 Receptor alpha Subunit - biosynthesis ; Interleukin-7 Receptor alpha Subunit - genetics ; Interleukin-7 Receptor alpha Subunit - metabolism ; Male ; Mice ; Mice, Knockout ; Promoter Regions, Genetic - immunology ; Protein Binding - immunology ; Proto-Oncogene Protein c-ets-1 - deficiency ; Proto-Oncogene Protein c-ets-1 - genetics ; Proto-Oncogene Protein c-ets-1 - metabolism ; Proto-Oncogene Protein c-ets-1 - physiology ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; T-Lymphocyte Subsets - virology
É parte de: The Journal of immunology (1950), 2011-01, Vol.186 (2), p.969-976
Notas: ObjectType-Article-1
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Current address: Nichole Frahm, HIV Vaccine Trials Network, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Descrição: The expression of CD127, the IL-7-binding subunit of the IL-7 R, is tightly regulated during the development and activation of T cells and is reduced during chronic viral infection. However, the molecular mechanism regulating the dynamic expression of CD127 is still poorly understood. In this study, we report that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells. Ets-1 binds to and activates the CD127 promoter, and its absence leads to reduced CD127 expression, attenuated IL-7 signaling, and impaired IL-7-dependent homeostatic proliferation of T cells. The expression of CD127 and Ets-1 is strongly correlated in human T cells. Both CD127 and Ets-1 expression are decreased in CD8(+) T cells during HIV infection. In addition, HIV-associated loss of CD127 is only observed in Ets-1(low) effector memory and central memory but not in Ets-1(high) naive CD8(+) T cells. Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells.
Editor: United States
Idioma: Inglês

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Ets-1 maintains IL-7 receptor expression in peripheral T cells

Grenningloh, Roland ; Tai, Tzong-Shyuan ; Frahm, Nicole ; Hongo, Tomoyuki C ; Chicoine, Adam T ; Brander, Christian ; Kaufmann, Daniel E ; Ho, I-Cheng

United States

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