Idioma:

Multiple Genes for Essential-Hypertension Susceptibility on Chromosome 1q

Chang, Yen-Pei Christy ; Liu, Xin ; Kim, James Dae Ok ; Ikeda, Morna A. ; Layton, Marnie R. ; Weder, Alan B. ; Cooper, Richard S. ; Kardia, Sharon L.R. ; Rao, D.C. ; Hunt, Steve C. ; Luke, Amy ; Boerwinkle, Eric ; Chakravarti, Aravinda

American journal of human genetics, 2007-02, Vol.80 (2), p.253-264 [Periódico revisado por pares]

Chicago, IL: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Multiple Genes for Essential-Hypertension Susceptibility on Chromosome 1q
Autor: Chang, Yen-Pei Christy ; Liu, Xin ; Kim, James Dae Ok ; Ikeda, Morna A. ; Layton, Marnie R. ; Weder, Alan B. ; Cooper, Richard S. ; Kardia, Sharon L.R. ; Rao, D.C. ; Hunt, Steve C. ; Luke, Amy ; Boerwinkle, Eric ; Chakravarti, Aravinda
Assuntos: Adolescent ; Adult ; Alleles ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Chromosomes, Human, Pair 1 - genetics ; Classical genetics, quantitative genetics, hybrids ; E-Selectin - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects. Genetic counseling ; Genetic Linkage ; Genetic Predisposition to Disease ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Human ; Human ; Humans ; Hypertension - genetics ; Male ; Medical genetics ; Medical sciences ; Middle Aged ; Molecular and cellular biology ; Phenotype ; Polymorphism, Single Nucleotide ; RGS Proteins - genetics ; Sodium-Potassium-Exchanging ATPase - genetics
É parte de: American journal of human genetics, 2007-02, Vol.80 (2), p.253-264
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Essential hypertension, defined as elevated levels of blood pressure (BP) without any obvious cause, is a major risk factor for coronary heart disease, stroke, and renal disease. BP levels and susceptibility to development of essential hypertension are partially determined by genetic factors that are poorly understood. Similar to other efforts to understand complex, non-Mendelian phenotypes, genetic dissection of hypertension-related traits employs genomewide linkage analyses of families and association studies of patient cohorts, to uncover rare and common disease alleles, respectively. Family-based mapping studies of elevated BP cover the large intermediate ground for identification of genes with common variants of significant effect. Our genomewide linkage and candidate-gene–based association studies demonstrate that a replicated linkage peak for BP regulation on human chromosome 1q, homologous to mouse and rat quantitative trait loci for BP, contains at least three genes associated with BP levels in multiple samples: ATP1B1, RGS5, and SELE. Individual variants in these three genes account for 2–5-mm Hg differences in mean systolic BP levels, and the cumulative effect reaches 8–10 mm Hg. Because the associated alleles in these genes are relatively common (frequency >5%), these three genes are important contributors to elevated BP in the population at large.
Editor: Chicago, IL: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Multiple Genes for Essential-Hypertension Susceptibility on Chromosome 1q

Chang, Yen-Pei Christy ; Liu, Xin ; Kim, James Dae Ok ; Ikeda, Morna A. ; Layton, Marnie R. ; Weder, Alan B. ; Cooper, Richard S. ; Kardia, Sharon L.R. ; Rao, D.C. ; Hunt, Steve C. ; Luke, Amy ; Boerwinkle, Eric ; Chakravarti, Aravinda

Chicago, IL: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.