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Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction

McGhie, A.Iain ; Corbett, James R. ; Akers, Marvin S. ; Kulkarni, Padmakur ; Sills, Michael N. ; Kremers, Mark ; Buja, L.Maximilian ; Durant-Reville, Marc ; Parkey, Robert W. ; Willerson, James T.

The American journal of cardiology, 1991-02, Vol.67 (4), p.236-242 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction
Autor: McGhie, A.Iain ; Corbett, James R. ; Akers, Marvin S. ; Kulkarni, Padmakur ; Sills, Michael N. ; Kremers, Mark ; Buja, L.Maximilian ; Durant-Reville, Marc ; Parkey, Robert W. ; Willerson, James T.
Assuntos: 3-Iodobenzylguanidine ; 550601 - Medicine- Unsealed Radionuclides in Diagnostics ; Adult ; Aged ; Arrhythmias, Cardiac - complications ; BETA DECAY RADIOISOTOPES ; Biological and medical sciences ; BIOMEDICAL RADIOGRAPHY ; BODY ; Cardiology. Vascular system ; CARDIOVASCULAR DISEASES ; CARDIOVASCULAR SYSTEM ; Catecholamines - blood ; COMPUTERIZED TOMOGRAPHY ; Contrast Media ; Coronary heart disease ; DIAGNOSIS ; DIAGNOSTIC TECHNIQUES ; DISEASES ; ELECTRON CAPTURE RADIOISOTOPES ; EMISSION COMPUTED TOMOGRAPHY ; Female ; HEART ; HOURS LIVING RADIOISOTOPES ; Humans ; IMAGE PROCESSING ; INTERMEDIATE MASS NUCLEI ; IODINE 123 ; IODINE ISOTOPES ; Iodine Radioisotopes ; Iodobenzenes ; ISOTOPES ; Male ; Medical sciences ; MEDICINE ; Middle Aged ; MYOCARDIAL INFARCTION ; Myocardial Infarction - complications ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - physiopathology ; NUCLEAR MEDICINE ; NUCLEI ; ODD-EVEN NUCLEI ; ORGANS ; PATIENTS ; PROCESSING ; RADIOISOTOPES ; RADIOLOGY ; RADIOLOGY AND NUCLEAR MEDICINE ; Sympathetic Nervous System - physiopathology ; Thallium Radioisotopes ; TOMOGRAPHY ; Tomography, Emission-Computed ; Ventricular Function, Left
É parte de: The American journal of cardiology, 1991-02, Vol.67 (4), p.236-242
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The effect of acute myocardial infarction (AMI) on regional cardiac adrenergic function was studied in 27 patients mean ± standard deviation 10 ± 4 days after AMI. Regional adrenergk function was evaluated noninvasively with I-123 meta-iodobenzylguanidine (MIBG) using a dedicated 3-detector tomograph. Four hours after its administration, there was reduced MIBG uptake in the region of infarction, 0.38 ± 0.31 counts/pixel/mCi × 103 compared with 0.60 ± 0.30 counts/pixel/mCi × 103 and 0.92 ± 0.35 counts/pixel/mCi × 103 in the zones bordering and distant from the infarct area, respectively, p < 0.001. In all patients, the area of reduced MIBG uptake after 4 hours was more extensive than the associated thallium-201 perfusion defect with defect scores of 52 ± 22 and 23 ± 18%, respectively, p < 0.001. After anterior wall AMI, the 4-hour MIBG defect score was 70 ± 13% and the degree of mismatch between myocardial perfusion and MIBG uptake was 30 ± 9% compared with 39 ± 17 and 21 ± 17% after inferior AMI, p < 0.001 and p = 0.016, respectively. The 4-hour MIBG defect score correlated inversely with the predischarge left ventricular ejection fraction, r = −0.73, p < 0.001. Patients with ventricular arrhythmia of ≥1 ventricular premature complexes per hour, paired ventricular premature complexes or ventricular tachycardia detected during the late hospital phase had higher 4-hour MIBG defect scores, 62.5 ± 15.0%, than patients with no detectable complex ventricular ectopic activity and a ventricular premature complex frequency of <1 per hour, 44.6 ± 23.4%, p = 0.036. These data suggest that after acute AMI in humans (1) the abnormality in adrenergic function is more extensive than the associated abnormality in myocardial perfusion; (2) anterior wall AMI is associated with greater disruption of cardiac adrenergic function than other infarcts; (3) the severity of cardiac adrenergic dysfunction correlates with the degree of left ventricular dysfunction; and (4) the abnormality in regional adrenergic function may be associated with the presence of ventricular ectopic activity after AMI.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Regional cardiac adrenergic function using I-123 meta-iodobenzylguanidine tomographic imaging after acute myocardial infarction

McGhie, A.Iain ; Corbett, James R. ; Akers, Marvin S. ; Kulkarni, Padmakur ; Sills, Michael N. ; Kremers, Mark ; Buja, L.Maximilian ; Durant-Reville, Marc ; Parkey, Robert W. ; Willerson, James T.

New York, NY: Elsevier Inc

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