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Next-generation DNA sequencing informatics

Stuart M. Brown 1962-

New York Cold Spring Harbor Laboratory Press 2015

Localização: IME - Inst. Matemática e Estatística    (QH507.C3 B879n 2. ed )(Acessar)

  • Título:
    Next-generation DNA sequencing informatics
  • Autor: Stuart M. Brown 1962-
  • Assuntos: Nucleotide sequenc Provided by publisher; Bioinformatics Provided by publisher; SCIENCE / Life Sciences / Biology / Molecular Biology Provided by publisher; SCIENCE / Life Sciences / Genetics & Genomics Provided by publisher; MEDICAL / Genetics Provided by publisher; BIOINFORMÁTICA; ANÁLISE DE SEQUÊNCIA DE DNA; BIOLOGIA MOLECULAR; GENÉTICA; GENÔMICA; COLETÂNEA
  • Notas: Includes bibliographical references and index
  • Descrição: Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applications including variant (mutation) discovery, gene expression, transcription factor analysis, metagenomics, and epigenetics. Bioinformatics methods to support DNA sequencing have become and remain a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. Next-Generation DNA Sequencing Bioinformatics, Second Edition, provides thorough, plain language introduction to the necessary informatics methods and tools for analyzing NGS data as did the first edition, and provides detailed descriptions of algorithms, strengths and weaknesses of specific tools, pitfalls and alternative methods. Four new chapters in this edition cover: experimental design, sample preparation, and quality assessment of NGS data; Public databases for DNA Sequencing data; De novo transcript assembly; proteogenomics; and emerging sequencing technologies. The remaining chapters from the first edition have been updated with the latest information. This book also provides extensive reference to best-practice bioinformatics methods for NGS applications and tutorials for common workflows. The second edition of Next-Generation DNA Sequencing Bioinformatics addresses the informatics needs of students, laboratory scientists, and computing specialists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies--
    Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. This book provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data--
  • Editor: New York Cold Spring Harbor Laboratory Press
  • Data de criação/publicação: 2015
  • Formato: xiv, 402 p ill. (some color) 27 cm..
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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