Idioma:

Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system

Gritsch, Simon ; Batchelor, Tracy T. ; Gonzalez Castro, L. Nicolas

Cancer, 2022-01, Vol.128 (1), p.47-58 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system
Autor: Gritsch, Simon ; Batchelor, Tracy T. ; Gonzalez Castro, L. Nicolas
Assuntos: 2021 World Health Organization (WHO) central nervous system (CNS) tumor classification ; Adult ; Brain cancer ; Brain Neoplasms - diagnosis ; Brain Neoplasms - therapy ; Brain tumors ; Central nervous system ; Central Nervous System - pathology ; Central Nervous System Neoplasms - diagnosis ; Central Nervous System Neoplasms - genetics ; Central Nervous System Neoplasms - therapy ; Child ; Classification ; Clinical trials ; glioblastoma ; glioma ; Glioma - pathology ; Humans ; isocitrate dehydrogenase (IDH)‐mutant gliomas ; Isocitrate Dehydrogenase - genetics ; meningiomas ; Mutation ; Nervous system ; Pathophysiology ; Pediatrics ; Prognosis ; Spinal cord ; Tumors ; World Health Organization
É parte de: Cancer, 2022-01, Vol.128 (1), p.47-58
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The 2016 revised fourth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors incorporated molecular features with histologic grading, revolutionizing how oncologists conceptualize primary brain and spinal cord tumors as well as providing new insights into their management and prognosis. The 2021 revised fifth edition of the WHO classification further integrates molecular alterations for CNS tumor categorization, updating current understanding of the pathophysiology of many of these disease entities. Here, the authors review changes in the new classification for the most common primary adult tumors—gliomas (including astrocytomas, oligodendrogliomas, and ependymomas) and meningiomas—highlighting the key genomic alterations for each group classification to help clinicians interpret them as they consider therapeutic options—including clinical trials and targeted therapies—and discuss the prognosis of these tumors with their patients. The revised, updated 2021 WHO classification also further integrates molecular alterations in the classification of pediatric CNS tumors, but those are not covered in the current review. The 2021 World Health Organization classification of tumors of the central nervous system increasingly relies on molecular alterations for central nervous system tumor categorization. The new classification will help improve diagnosis, prognosis, and treatment selection (including enrollment into relevant clinical trials) for patients with brain tumors.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system

Gritsch, Simon ; Batchelor, Tracy T. ; Gonzalez Castro, L. Nicolas

United States: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.