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SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2

Søreng, Kristiane ; Munson, Michael J ; Lamb, Christopher A ; Bjørndal, Gunnveig T ; Pankiv, Serhiy ; Carlsson, Sven R ; Tooze, Sharon A ; Simonsen, Anne

EMBO reports, 2018-04, Vol.19 (4), p.n/a [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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Título:
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2
Autor: Søreng, Kristiane ; Munson, Michael J ; Lamb, Christopher A ; Bjørndal, Gunnveig T ; Pankiv, Serhiy ; Carlsson, Sven R ; Tooze, Sharon A ; Simonsen, Anne
Assuntos: ATG9 ; Autophagy ; Autophagy-Related Proteins - metabolism ; Budding ; Carrier Proteins - metabolism ; Dynamin ; Dynamin II - metabolism ; Endosomes ; Endosomes - metabolism ; Golgi apparatus ; GTPase-Activating Proteins - metabolism ; Humans ; Intracellular Membranes - metabolism ; Membrane proteins ; Membrane Proteins - metabolism ; Membranes ; Models, Biological ; Phagocytosis ; Phosphate-Binding Proteins ; Protein Binding ; Protein Transport ; Protein turnover ; Recycling ; recycling endosome ; Scientific Report ; Scientific Reports ; SNX18 ; Sorting Nexins - metabolism ; Tubules ; Vesicular Transport Proteins - metabolism
É parte de: EMBO reports, 2018-04, Vol.19 (4), p.n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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The copyright line of this article was changed on 14 March 2018 after original online publication.
Descrição: Trafficking of mammalian ATG9A between the Golgi apparatus, endosomes and peripheral ATG9A compartments is important for autophagosome biogenesis. Here, we show that the membrane remodelling protein SNX18, previously identified as a positive regulator of autophagy, regulates ATG9A trafficking from recycling endosomes. ATG9A is recruited to SNX18‐induced tubules generated from recycling endosomes and accumulates in juxtanuclear recycling endosomes in cells lacking SNX18. Binding of SNX18 to Dynamin‐2 is important for ATG9A trafficking from recycling endosomes and for formation of ATG16L1‐ and WIPI2‐positive autophagosome precursor membranes. We propose a model where upon autophagy induction, SNX18 recruits Dynamin‐2 to induce budding of ATG9A and ATG16L1 containing membranes from recycling endosomes that traffic to sites of autophagosome formation. Synopsis SNX18 recruits Dynamin‐2 to transport ATG9A and ATG16L1 from juxtanuclear recycling endosomes to pre‐autophagic structures. SNX18 interacts with Dynamin‐2 to facilitate trafficking of ATG9A and ATG16L1 from recycling endosomes to sites of autophagosome formation. ATG9A accumulates in juxtanuclear recycling endosomes in SNX18 KO cells. SNX18 recruits Dynamin‐2 to transport ATG9A and ATG16L1 from juxtanuclear recycling endosomes to pre‐autophagic structures.
Editor: England: Blackwell Publishing Ltd
Idioma: Inglês;Norueguês

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SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2

Søreng, Kristiane ; Munson, Michael J ; Lamb, Christopher A ; Bjørndal, Gunnveig T ; Pankiv, Serhiy ; Carlsson, Sven R ; Tooze, Sharon A ; Simonsen, Anne

England: Blackwell Publishing Ltd

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