Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Chappell, Mark D ; Li, Renhua ; Smith, Stephon C ; Dressman, Bruce A ; Tromiczak, Eric G ; Tripp, Allie E ; Blanco, Maria-Jesus ; Vetman, Tatiana ; Quimby, Steven J ; Matt, James ; Britton, Thomas C ; Fivush, Adam M ; Schkeryantz, Jeffrey M ; Mayhugh, Daniel ; Erickson, Jon A ; Bures, Mark G ; Jaramillo, Carlos ; Carpintero, Mercedes ; Diego, José Eugenio de ; Barberis, Mario ; Garcia-Cerrada, Susana ; Soriano, José F ; Antonysamy, Stephen ; Atwell, Shane ; MacEwan, Iain ; Condon, Bradley ; Sougias, Christine ; Wang, Jing ; Zhang, Aiping ; Conners, Kris ; Groshong, Chris ; Wasserman, Stephen R ; Koss, John W ; Witkin, Jeffrey M ; Li, Xia ; Overshiner, Carl ; Wafford, Keith A ; Seidel, Wesley ; Wang, Xu-Shan ; Heinz, Beverly A ; Swanson, Steven ; Catlow, John T ; Bedwell, David W ; Monn, James A ; Mitch, Charles H ; Ornstein, Paul L

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10974-10993 [Periódico revisado por pares]

United States: American Chemical Society

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