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Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach

Mallad, Ashwini ; Hinshaw, Ling ; Schiavon, Michele ; Dalla Man, Chiara ; Dadlani, Vikash ; Basu, Rita ; Lingineni, Ravi ; Cobelli, Claudio ; Johnson, Matthew L ; Carter, Rickey ; Kudva, Yogish C ; Basu, Ananda

American journal of physiology: endocrinology and metabolism, 2015-06, Vol.308 (12), p.E1106-E1115 [Periódico revisado por pares]

United States: American Physiological Society

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Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach
Autor: Mallad, Ashwini ; Hinshaw, Ling ; Schiavon, Michele ; Dalla Man, Chiara ; Dadlani, Vikash ; Basu, Rita ; Lingineni, Ravi ; Cobelli, Claudio ; Johnson, Matthew L ; Carter, Rickey ; Kudva, Yogish C ; Basu, Ananda
Assuntos: Adolescent ; Adult ; Aged ; Blood Glucose - metabolism ; Diabetes ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - metabolism ; Exercise ; Exercise - physiology ; Exercise Test ; Female ; Gastric Emptying ; Glucose ; Humans ; Insulin ; Insulin - administration & dosage ; Insulin - metabolism ; Insulin Infusion Systems ; Male ; Metabolism ; Middle Aged ; Physical fitness ; Physiology ; Postprandial Period ; Young Adult
É parte de: American journal of physiology: endocrinology and metabolism, 2015-06, Vol.308 (12), p.E1106-E1115
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A. Mallad and L. Hinshaw contributed equally to this article.
Descrição: To determine the effects of exercise on postprandial glucose metabolism and insulin action in type 1 diabetes (T1D), we applied the triple tracer technique to study 16 T1D subjects on insulin pump therapy before, during, and after 75 min of moderate-intensity exercise (50% V̇o2max) that started 120 min after a mixed meal containing 75 g of labeled glucose. Prandial insulin bolus was administered as per each subject's customary insulin/carbohydrate ratio adjusted for meal time meter glucose and the level of physical activity. Basal insulin infusion rates were not altered. There were no episodes of hypoglycemia during the study. Plasma dopamine and norepinephrine concentrations rose during exercise. During exercise, rates of endogenous glucose production rose rapidly to baseline levels despite high circulating insulin and glucose concentrations. Interestingly, plasma insulin concentrations increased during exercise despite no changes in insulin pump infusion rates, implying increased mobilization of insulin from subcutaneous depots. Glucagon concentrations rose before and during exercise. Therapeutic approaches for T1D management during exercise will need to account for its effects on glucose turnover, insulin mobilization, glucagon, and sympathetic response and possibly other blood-borne feedback and afferent reflex mechanisms to improve both hypoglycemia and hyperglycemia.
Editor: United States: American Physiological Society
Idioma: Inglês

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Exercise effects on postprandial glucose metabolism in type 1 diabetes: a triple-tracer approach

Mallad, Ashwini ; Hinshaw, Ling ; Schiavon, Michele ; Dalla Man, Chiara ; Dadlani, Vikash ; Basu, Rita ; Lingineni, Ravi ; Cobelli, Claudio ; Johnson, Matthew L ; Carter, Rickey ; Kudva, Yogish C ; Basu, Ananda

United States: American Physiological Society

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