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Genomic and phenotypic heterogeneity in prostate cancer

Haffner, Michael C ; Zwart, Wilbert ; Roudier, Martine P ; True, Lawrence D ; Nelson, William G ; Epstein, Jonathan I ; De Marzo, Angelo M ; Nelson, Peter S ; Yegnasubramanian, Srinivasan

Nature reviews. Urology, 2021-02, Vol.18 (2), p.79-92 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Genomic and phenotypic heterogeneity in prostate cancer
Autor: Haffner, Michael C ; Zwart, Wilbert ; Roudier, Martine P ; True, Lawrence D ; Nelson, William G ; Epstein, Jonathan I ; De Marzo, Angelo M ; Nelson, Peter S ; Yegnasubramanian, Srinivasan
Assuntos: Biomarkers, Tumor - blood ; Cancer ; Care and treatment ; Development and progression ; Epigenesis, Genetic ; Epigenetic inheritance ; Genetic aspects ; Genetic Heterogeneity ; Genome ; Genomics ; Genotype ; Health aspects ; Humans ; Male ; Medical colleges ; Medical research ; Medicine, Experimental ; Metastasis ; Neoplasm Metastasis - genetics ; Neoplasms, Multiple Primary - genetics ; Neoplasms, Multiple Primary - pathology ; Phenotype ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - therapy ; Prostatic Neoplasms, Castration-Resistant - genetics ; Prostatic Neoplasms, Castration-Resistant - pathology ; Prostatic Neoplasms, Castration-Resistant - therapy ; Treatment Outcome
É parte de: Nature reviews. Urology, 2021-02, Vol.18 (2), p.79-92
Notas: ObjectType-Article-1
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ObjectType-Review-2
M.C.H., J.I.E., P.S.N. and S.Y. researched data for the article, made a substantial contribution to discussion of content, wrote and reviewed/edited the manuscript before submission. W.Z. and M.P.R. researched data for the article, made a substantial contribution to discussion of content and reviewed/edited the manuscript before submission. L.D.T. reviewed/edited the manuscript before submission. W.G.N. made a substantial contribution to discussion of content and reviewed/edited the manuscript before submission. A.M.D.M. made a substantial contribution to discussion of content, wrote and reviewed/edited the manuscript before submission.
Author contributions
Descrição: From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having topographically and morphologically distinct tumour foci. Sequencing studies have revealed that individual tumour foci can arise as clonally distinct lesions with no shared driver gene alterations. This finding demonstrates that multiple genomically and phenotypically distinct primary prostate cancers can be present in an individual patient. Lethal metastatic prostate cancer seems to arise from a single clone in the primary tumour but can exhibit subclonal heterogeneity at the genomic, epigenetic and phenotypic levels. Collectively, this complex heterogeneous constellation of molecular alterations poses obstacles for the diagnosis and treatment of prostate cancer. However, advances in our understanding of intra-tumoural heterogeneity and the development of novel technologies will allow us to navigate these challenges, refine approaches for translational research and ultimately improve patient care.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Genomic and phenotypic heterogeneity in prostate cancer

Haffner, Michael C ; Zwart, Wilbert ; Roudier, Martine P ; True, Lawrence D ; Nelson, William G ; Epstein, Jonathan I ; De Marzo, Angelo M ; Nelson, Peter S ; Yegnasubramanian, Srinivasan

England: Nature Publishing Group

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