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Ambulatory Hypertension Subtypes and 24-Hour Systolic and Diastolic Blood Pressure as Distinct Outcome Predictors in 8341 Untreated People Recruited From 12 Populations

Li, Yan ; Wei, Fang-Fei ; Thijs, Lutgarde ; Boggia, José ; Asayama, Kei ; Hansen, Tine W ; Kikuya, Masahiro ; Björklund-Bodegård, Kristina ; Ohkubo, Takayoshi ; Jeppesen, Jørgen ; Gu, Yu-Mei ; Torp-Pedersen, Christian ; Dolan, Eamon ; Liu, Yan-Ping ; Kuznetsova, Tatiana ; Stolarz-Skrzypek, Katarzyna ; Tikhonoff, Valérie ; Malyutina, Sofia ; Casiglia, Edoardo ; Nikitin, Yuri ; Lind, Lars ; Sandoya, Edgardo ; Kawecka-Jaszcz, Kalina ; Mena, Luis ; Maestre, Gladys E ; Filipovský, Jan ; Imai, Yutaka ; O’Brien, Eoin ; Wang, Ji-Guang ; Staessen, Jan A

Circulation (New York, N.Y.), 2014-08, Vol.130 (6), p.466-474 [Periódico revisado por pares]

Hagerstown, MD: by the American College of Cardiology Foundation and the American Heart Association, Inc

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Título:
Ambulatory Hypertension Subtypes and 24-Hour Systolic and Diastolic Blood Pressure as Distinct Outcome Predictors in 8341 Untreated People Recruited From 12 Populations
Autor: Li, Yan ; Wei, Fang-Fei ; Thijs, Lutgarde ; Boggia, José ; Asayama, Kei ; Hansen, Tine W ; Kikuya, Masahiro ; Björklund-Bodegård, Kristina ; Ohkubo, Takayoshi ; Jeppesen, Jørgen ; Gu, Yu-Mei ; Torp-Pedersen, Christian ; Dolan, Eamon ; Liu, Yan-Ping ; Kuznetsova, Tatiana ; Stolarz-Skrzypek, Katarzyna ; Tikhonoff, Valérie ; Malyutina, Sofia ; Casiglia, Edoardo ; Nikitin, Yuri ; Lind, Lars ; Sandoya, Edgardo ; Kawecka-Jaszcz, Kalina ; Mena, Luis ; Maestre, Gladys E ; Filipovský, Jan ; Imai, Yutaka ; O’Brien, Eoin ; Wang, Ji-Guang ; Staessen, Jan A
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; ambulatory blood pressure monitoring ; Blood Pressure - physiology ; blood pressure component ; Blood Pressure Monitoring, Ambulatory - methods ; cardiovascular diseases ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Hypertension - diagnosis ; Hypertension - epidemiology ; Hypertension - physiopathology ; Male ; Medicin och hälsovetenskap ; Middle Aged ; population ; Population Surveillance - methods ; Predictive Value of Tests ; Treatment Outcome ; Young Adult
É parte de: Circulation (New York, N.Y.), 2014-08, Vol.130 (6), p.466-474
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: BACKGROUND—Data on risk associated with 24-hour ambulatory diastolic (DBP24) versus systolic (SBP24) blood pressure are scarce. METHODS AND RESULTS—We recorded 24-hour blood pressure and health outcomes in 8341 untreated people (mean age, 50.8 years; 46.6% women) randomly recruited from 12 populations. We computed hazard ratios (HRs) using multivariable-adjusted Cox regression. Over 11.2 years (median), 927 (11.1%) participants died, 356 (4.3%) from cardiovascular causes, and 744 (8.9%) experienced a fatal or nonfatal cardiovascular event. Isolated diastolic hypertension (DBP24≥80 mm Hg) did not increase the risk of total mortality, cardiovascular mortality, or stroke (HRs≤1.54; P≥0.18), but was associated with a higher risk of fatal combined with nonfatal cardiovascular, cardiac, or coronary events (HRs≥1.75; P≤0.0054). Isolated systolic hypertension (SBP24≥130 mm Hg) and mixed diastolic plus systolic hypertension were associated with increased risks of all aforementioned end points (P≤0.0012). Below age 50, DBP24 was the main driver of risk, reaching significance for total (HR for 1-SD increase, 2.05; P=0.0039) and cardiovascular mortality (HR, 4.07; P=0.0032) and for all cardiovascular end points combined (HR, 1.74; P=0.039) with a nonsignificant contribution of SBP24 (HR≤0.92; P≥0.068); above age 50, SBP24 predicted all end points (HR≥1.19; P≤0.0002) with a nonsignificant contribution of DBP24 (0.96≤HR≤1.14; P≥0.10). The interactions of age with SBP24 and DBP24 were significant for all cardiovascular and coronary events (P≤0.043). CONCLUSIONS—The risks conferred by DBP24 and SBP24 are age dependent. DBP24 and isolated diastolic hypertension drive coronary complications below age 50, whereas above age 50 SBP24 and isolated systolic and mixed hypertension are the predominant risk factors.
Editor: Hagerstown, MD: by the American College of Cardiology Foundation and the American Heart Association, Inc
Idioma: Inglês;Russo

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Ambulatory Hypertension Subtypes and 24-Hour Systolic and Diastolic Blood Pressure as Distinct Outcome Predictors in 8341 Untreated People Recruited From 12 Populations

Hagerstown, MD: by the American College of Cardiology Foundation and the American Heart Association, Inc

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