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Endocrine‐related quality of life in a randomized trial of exercise on aromatase inhibitor–induced arthralgias in breast cancer survivors

Baglia, Michelle L. ; Lin, I‐Hsin ; Cartmel, Brenda ; Sanft, Tara ; Ligibel, Jennifer ; Hershman, Dawn L. ; Harrigan, Maura ; Ferrucci, Leah M. ; Li, Fang‐Yong ; Irwin, Melinda L.

Cancer, 2019-07, Vol.125 (13), p.2262-2271 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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  • Título:
    Endocrine‐related quality of life in a randomized trial of exercise on aromatase inhibitor–induced arthralgias in breast cancer survivors
  • Autor: Baglia, Michelle L. ; Lin, I‐Hsin ; Cartmel, Brenda ; Sanft, Tara ; Ligibel, Jennifer ; Hershman, Dawn L. ; Harrigan, Maura ; Ferrucci, Leah M. ; Li, Fang‐Yong ; Irwin, Melinda L.
  • Assuntos: Aromatase ; aromatase inhibitors ; Aromatase Inhibitors - adverse effects ; Arthralgia ; Arthralgia - chemically induced ; Arthralgia - psychology ; Arthralgia - therapy ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Cancer Survivors - psychology ; Endocrine System - drug effects ; Exercise ; Exercise Therapy - methods ; Female ; Follow-Up Studies ; Hormones ; Humans ; Inhibitors ; Intervention ; Middle Aged ; Patient Compliance - psychology ; Patient Compliance - statistics & numerical data ; Physical exercise ; Physical fitness ; Physical training ; Prognosis ; Quality of Life ; randomized controlled trial ; Side effects ; Surveys and Questionnaires ; Survival ; Training ; Treadmills ; Walking
  • É parte de: Cancer, 2019-07, Vol.125 (13), p.2262-2271
  • Notas: Author Contributions: Michelle Baglia: Formal analysis, writing – original draft, writing - review and editing. I-Hsin Lin: Formal analysis, writing – review and editing. Brenda Cartmel: Conceptualization, investigation, methodology, project administration, supervision, writing – review and editing. Tara Sanft: writing – methodology, review and editing. Jennifer Ligibel: writing – conceptualization, methodology, review and editing. Dawn L. Hershman: writing – conceptualization review, methodology and editing. Maura Harrigan: project administration, writing – review and editing. Leah M. Ferrucci: writing – review and editing. Fang-Yong Li: Formal analysis, writing – review and editing. Melinda L. Irwin: Conceptualization, funding acquisition, investigation, methodology, project administration, resources, supervision, writing – review and editing.
  • Descrição: Background The objective of this study was to evaluate the role of a 12‐month exercise intervention on endocrine‐related quality of life (QOL) and overall QOL among breast cancer survivors with aromatase inhibitor (AI)‐induced arthralgia in the Hormones and Physical Exercise (HOPE) Study. Methods This was a randomized controlled trial of 121 breast cancer survivors who were currently receiving AIs and experiencing at least mild arthralgia. QOL was assessed using the Functional Assessment of Cancer Therapy (FACT) questionnaires and the 36‐Item Short Form Survey (SF‐36) at baseline, 6 months, and 12 months. Participants were randomized to either a 1‐year gym‐based, supervised exercise intervention group (150 minutes of aerobic exercise and 2 strength‐training sessions each week) or a usual care group. Effects of the intervention on QOL were assessed using mixed‐model, repeated‐measures analysis. Results At 12 months, the exercise group had greater improvement in the overall QOL measures as well as the breast cancer‐specific (scores, 2.2 vs 0.7; P = .02), endocrine‐specific (scores, 5.6 vs 1.6; P < .001), and fatigue‐specific (score, 5.8 vs 0.5; P < .001) subscales compared with the usual care group. The results indicated a stronger effect at 12 months versus 6 months after the intervention. Conclusions Combined aerobic and resistance exercise, such as treadmill walking and strength training, improved endocrine‐related and overall QOL among breast cancer survivors who were experiencing adverse side effects from AIs. Because adverse side effects associated with AI use are quite common and this is the main reason for treatment discontinuation, this nonpharmacologic intervention could benefit many breast cancer survivors and increase successful adherence to AIs in breast cancer treatment. Combined aerobic exercise, such as treadmill walking and strength training, improves endocrine‐related and overall quality of life among breast cancer survivors who experience adverse side effects from aromatase inhibitors. This nonpharmacologic intervention could benefit many breast cancer survivors because the adverse side effects associated with aromatase inhibitors are quite common and are the main reason for treatment discontinuation.
  • Editor: United States: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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