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Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases

Ospina, P.A. ; Nydam, D.V. ; Stokol, T. ; Overton, T.R.

Journal of dairy science, 2010-02, Vol.93 (2), p.546-554 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases
Autor: Ospina, P.A. ; Nydam, D.V. ; Stokol, T. ; Overton, T.R.
Assuntos: 3-Hydroxybutyric Acid - blood ; Animal productions ; Animals ; beta-hydroxybutyrate ; Biological and medical sciences ; butyrates ; Cattle ; cattle diseases ; Cattle Diseases - blood ; Cattle Diseases - diagnosis ; clinical examination ; cow feeding ; dairy cow ; dairy cows ; Dairying - methods ; disease ; displaced abomasum ; endometritis ; energy balance ; Fatty Acids, Nonesterified - blood ; Female ; Food industries ; free fatty acids ; Fundamental and applied biological sciences. Psychology ; herd health ; ketosis ; Milk and cheese industries. Ice creams ; New England ; nonesterified fatty acids ; perinatal period ; periparturient diseases and disorders ; prediction ; Predictive Value of Tests ; Pregnancy ; retained placenta ; risk assessment ; Risk Factors ; ruminant nutrition ; Terrestrial animal productions ; Vertebrates ; β-hydroxybutyrate
É parte de: Journal of dairy science, 2010-02, Vol.93 (2), p.546-554
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The objectives of this study were to 1) establish cow-level critical thresholds for serum concentrations of nonesterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) to predict periparturient diseases [displaced abomasa (DA), clinical ketosis (CK), metritis and retained placenta, or any of these three], and 2) investigate the magnitude of the metabolites’ association with these diseases within 30 d in milk. In a prospective cohort study of 100 freestall, total mixed ration-fed herds in the northeastern United States, blood samples were collected from approximately 15 prepartum and 15 different postpartum transition animals in each herd, for a total of 2,758 samples. Serum NEFA concentrations were measured in the prepartum group, and both NEFA and BHBA were measured in the postpartum group. The critical thresholds for NEFA or BHBA were evaluated with receiver operator characteristic analysis for all diseases in both cohorts. The risk ratios (RR) of a disease outcome given NEFA or BHBA concentrations and other covariates were modeled with multivariable regression techniques, accounting for clustering of cows within herds. The NEFA critical threshold that predicted any of the 3 diseases in the prepartum cohort was 0.29mEq/L and in the postpartum cohort was 0.57mEq/L. The critical threshold for serum BHBA in the postpartum cohort was 10mg/dL, which predicted any of the 3 diseases. All RR with NEFA as a predictor of disease were >1.8; however, RR were greatest in animals sampled postpartum (e.g., RR for DA=9.7; 95% CI=4.2 to 22.4. All RR with BHBA as the predictor of disease were >2.3 (e.g., RR for DA=6.9; 95% CI=3.7 to 12.9). Although prepartum NEFA and postpartum BHBA were both significantly associated with development of clinical disease, postpartum serum NEFA concentration was most associated with the risk of developing DA, CK, metritis, or retained placenta during the first 30 d in milk.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases

Ospina, P.A. ; Nydam, D.V. ; Stokol, T. ; Overton, T.R.

New York, NY: Elsevier Inc

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