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An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp

Marx, Tennille K. ; Reddeman, Robin ; Clewell, Amy E. ; Endres, John R. ; Béres, Erzsébet ; Vértesi, Adél ; Glávits, Róbert ; Hirka, Gábor ; Szakonyiné, Ilona Pasics Costa, Lucio Guido ; Lucio Guido Costa

Journal of toxicology, 2018-01, Vol.2018, p.8143582-26 [Periódico revisado por pares]

Egypt: Hindawi

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Título:
An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp
Autor: Marx, Tennille K. ; Reddeman, Robin ; Clewell, Amy E. ; Endres, John R. ; Béres, Erzsébet ; Vértesi, Adél ; Glávits, Róbert ; Hirka, Gábor ; Szakonyiné, Ilona Pasics
Costa, Lucio Guido ; Lucio Guido Costa
Assuntos: Analysis ; Batteries ; Biocompatibility ; Body weight ; Body weight gain ; Cannabinoids ; Cannabis ; Carbon dioxide ; Constituents ; Females ; Genotoxicity ; Hemp ; In vitro methods and tests ; In vivo methods and tests ; International conferences ; Laboratory animals ; Males ; Marijuana ; Mutation ; Nervous system ; Pathology ; Phenols (Class of compounds) ; Physiology ; Rangefinding ; Rats ; Recovery ; Reproductive system ; Sperm ; Studies ; Supercritical fluids ; Supercritical gas extraction ; Toxicity ; Toxicity testing
É parte de: Journal of toxicology, 2018-01, Vol.2018, p.8143582-26
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Lucio Guido Costa
Descrição: A battery of toxicological studies was conducted on a supercritical CO2 extract of the aerial parts of the Cannabis sativa plant, containing approximately 25% cannabinoids. No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames), in an in vitro mammalian chromosomal aberration test, or in an in vivo mouse micronucleus study. A 14-day repeated oral dose-range finding study conducted in Wistar rats at 1000, 2000, and 4000 mg/kg bw/day resulted in effects where a NOAEL could not be concluded. Based on those results, a 90-day repeated dose oral toxicity study was performed in rats using doses of 100, 360, and 720 mg/kg bw/day, followed by a 28-day recovery period for two satellite groups. Significant decreases in body weight, body weight gain, and differences in various organ weights compared to controls were observed. At the end of the recovery period, many of the findings were trending toward normal; thus, the changes appeared to be reversible. The NOAEL for the hemp extract in Hsd.Han Wistar rats was considered to be 100 mg/kg bw/day for males and 360 mg/kg bw/day for females.
Editor: Egypt: Hindawi
Idioma: Inglês

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An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp

Marx, Tennille K. ; Reddeman, Robin ; Clewell, Amy E. ; Endres, John R. ; Béres, Erzsébet ; Vértesi, Adél ; Glávits, Róbert ; Hirka, Gábor ; Szakonyiné, Ilona Pasics Costa, Lucio Guido ; Lucio Guido Costa

Egypt: Hindawi

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