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Nano-graphene in biomedicine: theranostic applications

Yang, Kai ; Feng, Liangzhu ; Shi, Xiaoze ; Liu, Zhuang

Chemical Society reviews, 2013-01, Vol.42 (2), p.53-547 [Periódico revisado por pares]

England

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  • Título:
    Nano-graphene in biomedicine: theranostic applications
  • Autor: Yang, Kai ; Feng, Liangzhu ; Shi, Xiaoze ; Liu, Zhuang
  • Assuntos: Animals ; Biocompatibility ; Drug Delivery Systems - methods ; Graphene ; Graphite - chemistry ; Graphite - therapeutic use ; Graphite - toxicity ; Humans ; Mice ; Nanomedicine - methods ; Nanostructure ; Nanostructures - chemistry ; Nanostructures - therapeutic use ; Nanostructures - toxicity ; Neoplasms - diagnosis ; Neoplasms - therapy ; Oxides ; Therapy ; Toxicity
  • É parte de: Chemical Society reviews, 2013-01, Vol.42 (2), p.53-547
  • Notas: Dr Zhuang Liu received his BS degree from Peking University (China) in 2004 and PhD degree from Stanford University (USA) in 2008. In 2009, Dr Liu joined Institute Functional Nano & Soft Materials (FUNSOM) at Soochow University in China as a principal investigator. Dr Liu's research in the past few years was mostly focused on the development of functional nanomaterials including carbon nanomaterials, upconversion nanoparticles, and other composite nanostructures, for applications in biomedical imaging, drug delivery, phototherapy of cancer, and stem cell research. Starting from 2005, Dr Liu has authored over 70 peer-reviewed papers, many of which were published on top chemistry, materials and biomedicine journals (total citation > 5000). The awards Dr Liu received include MRS silver award in 2008 and SCOPUS young researcher award (China) in 2012.
    Xiaoze Shi obtained her BS degree from College of Chemistry, Chemical Engineering and Materials Science of Soochow University in 2011. From then on she has been working on her Masters Degree at FUNSOM in Soochow University under the supervision of Prof. Zhuang Liu. Her research interest is the development of novel graphene-based nanocomposites for biomedical applications.
    Liangzhu Feng received his BS degree in Biological Sciences from the School of Biology and Basic Medical Sciences of Soochow University in 2010. Since then, he has been pursuing his PhD degree at FUNSOM of Soochow University under the supervision of Prof. Zhuang Liu. His research interest is focused on the controllable drug and gene delivery using functionalized nano-graphene.
    Kai Yang graduated in 2006 from the Anhui Polytechnic University with a BS degree in Biological Engineering. He completed his Masters Degree in the School of Medicine and Life Sciences, Medical College of Soochow University in 2009. He is now a PhD candidate in Institute of Functional Nano & Soft Materials (FUNSOM) at Soochow University under the supervision of Prof. Zhuang Liu. His dissertation title is biomedical applications of nano-graphene.
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  • Descrição: Owing to their unique physical and chemical properties, graphene and its derivatives such as graphene oxide (GO), reduced graphene oxide (RGO) and GO-nanocomposites have attracted tremendous interest in many different fields including biomedicine in recent years. With every atom exposed on its surface, single-layered graphene shows ultra-high surface area available for efficient molecular loading and bioconjugation, and has been widely explored as novel nano-carriers for drug and gene delivery. Utilizing the intrinsic near-infrared (NIR) optical absorbance, in vivo graphene-based photothermal therapy has been realized, achieving excellent anti-tumor therapeutic efficacy in animal experiments. A variety of inorganic nanoparticles can be grown on the surface of nano-graphene, obtaining functional graphene-based nanocomposites with interesting optical and magnetic properties useful for multi-modal imaging and imaging-guided cancer therapy. Moreover, significant efforts have also been devoted to study the behaviors and toxicology of functionalized nano-graphene in animals. It has been uncovered that both surface chemistry and sizes play key roles in controlling the biodistribution, excretion, and toxicity of nano-graphene. Biocompatibly coated nano-graphene with ultra-small sizes can be cleared out from body after systemic administration, without rendering noticeable toxicity to the treated mice. In this review article, we will summarize the latest progress in this rapidly growing field, and discuss future prospects and challenges of using graphene-based materials for theranostic applications. In this review article, we summarize the latest progress in the development of nano-graphene for drug delivery, cancer therapies, as well as biomedical imaging, and discuss future prospects and challenges in this rapidly growing field.
  • Editor: England
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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