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The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex

Amstadter, Ananda B. ; MacPherson, Laura ; Wang, Frances ; Banducci, Anne N. ; Reynolds, Elizabeth K. ; Potenza, Marc N. ; Gelernter, Joel ; Lejuez, C.W.

Journal of psychiatric research, 2012-07, Vol.46 (7), p.940-945 [Periódico revisado por pares]

Elsevier Ltd

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  • Título:
    The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex
  • Autor: Amstadter, Ananda B. ; MacPherson, Laura ; Wang, Frances ; Banducci, Anne N. ; Reynolds, Elizabeth K. ; Potenza, Marc N. ; Gelernter, Joel ; Lejuez, C.W.
  • Assuntos: Adolescents ; BART ; COMT Val158Met ; Dopamine ; Risk-taking
  • É parte de: Journal of psychiatric research, 2012-07, Vol.46 (7), p.940-945
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: Although adolescents frequently engage in a variety of risky behaviors, much remains unknown about the specific etiologies of such tendencies. Candidate genetic variants, such as the COMT Val158Met polymorphism, may be related to risk-taking propensity, particularly as this variant is linked to functional enzymatic differences influencing dopamine function in regions including the prefrontal cortex. The present study aimed to examine the COMT Val158Met variant in relation to risk-taking propensity in a community sample of youth. As part of a larger longitudinal study on adolescent risk behaviors, 223 youths (average age 11.3 years) from the metropolitan Washington D.C. area completed a measure of risk-taking propensity, the Balloon Analog Risk Task-Youth Version (BART-Y), and provided saliva samples for DNA extraction and genotyping. Results indicate that females, but not males, who are carriers of the COMT158Met allele had higher risk-taking propensity scores on the BART-Y compared to Val homozygotes. Analyses were also conducted in the 111 European American participants, and results were consistent with those of the full sample analyses. This study represents the first investigation of a genetic substrate of risk-taking propensity, measured by a behavioral task, in youth. Results should be taken as quite preliminary, given the small sample. Implications are discussed.
  • Editor: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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