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NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases

Binh, Mai Thanh ; Hoan, Nghiem Xuan ; Van Tong, Hoang ; Sy, Bui Tien ; Trung, Ngo Tat ; Bock, C.-Thomas ; Toan, Nguyen Linh ; Song, Le Huu ; Bang, Mai Hong ; Meyer, Christian G. ; Kremsner, Peter G. ; Velavan, Thirumalaisamy P.

International journal of infectious diseases, 2019-03, Vol.80, p.147-152 [Periódico revisado por pares]

Canada: Elsevier Ltd

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  • Título:
    NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases
  • Autor: Binh, Mai Thanh ; Hoan, Nghiem Xuan ; Van Tong, Hoang ; Sy, Bui Tien ; Trung, Ngo Tat ; Bock, C.-Thomas ; Toan, Nguyen Linh ; Song, Le Huu ; Bang, Mai Hong ; Meyer, Christian G. ; Kremsner, Peter G. ; Velavan, Thirumalaisamy P.
  • Assuntos: HBV ; HDV ; Liver diseases ; NTCP ; S267F
  • É parte de: International journal of infectious diseases, 2019-03, Vol.80, p.147-152
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •The NTCP S267F variant is associated with a lower risk of chronic HBV infection.•First study on NTCP S267F variant on concomitant HDV infection in Vietnamese population.•The NTCP S267F is correlated with a reduced risk on clinical progression of liver cirrhosis and liver cancer. To determine potential associations of the rs2296651 variant (c.800C>T, S267F) of NTCP with HBV and HBV plus concomitant HDV infection as well as with the progression of related liver diseases. The S267F variant was genotyped by DNA sequencing in 620 HBV-infected patients and 214 healthy controls (HCs). Among the patients, 450 individuals were tested for HDV by a nested PCR assay. Logistic regression was applied to examine the association. The S267F variant was found more frequently among HCs (16%) compared to HBV-infected (6%) and HBV-HDV co-infected patients (3%) (HBV patients vs HC: OR=0.32, P=0.00002 and HDV patients vs. HC: OR=0.17, P=0.018). The frequency of S267F variant was inversely correlated with CHB, LC or HCC patients compared with HCs (OR=0.31, P=0.001; OR=0.32, P=0.013; OR=0.34, P=0.002, respectively). S267F variant was also associated with decreased risk of the development of advanced liver cirrhosis (LC) and hepatocellular carcinoma (HCC) (Child B and C vs. Child A, OR=0.26, adjusted P=0.016; BCLC B,C,D vs. BCLC A, OR=0.038, P=0.045, respectively). In addition, patients with the genotype CT had lower levels of AST, ALT, total and direct bilirubin as well as higher platelet counts, indicating an association with a more favorable clinical outcome. The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of LC and HCC.
  • Editor: Canada: Elsevier Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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