Idioma:

Prevalence in myositis of antibodies recognizing anti‐U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin

Kubo, M. ; Ihn, H. ; Kuwana, M. ; Yamane, K. ; Yazawa, N. ; Tamaki, K.

Clinical and experimental immunology, 2001-11, Vol.126 (2), p.339-344 [Periódico revisado por pares]

Oxford, UK: Blackwell Science Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Prevalence in myositis of antibodies recognizing anti‐U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin
Autor: Kubo, M. ; Ihn, H. ; Kuwana, M. ; Yamane, K. ; Yazawa, N. ; Tamaki, K.
Assuntos: Adolescent ; Adult ; Aged ; Antibody Specificity ; antinuclear antibodies ; Autoantibodies - blood ; Biological and medical sciences ; Chromosomal Proteins, Non-Histone - chemistry ; Chromosomal Proteins, Non-Histone - immunology ; Chromosomal Proteins, Non-Histone - isolation & purification ; Dermatomyositis - immunology ; Female ; fibrillarin ; Fluorescent Antibody Technique, Indirect ; General aspects ; Humans ; Immunopathology ; Macromolecular Substances ; Male ; Medical sciences ; Middle Aged ; Molecular Weight ; Myo 22/25 antigen ; Polymyositis - immunology ; Precipitin Tests ; Rheumatic Disease/Vasculitis ; Ribonucleoproteins, Small Nucleolar - chemistry ; Ribonucleoproteins, Small Nucleolar - immunology ; Ribonucleoproteins, Small Nucleolar - isolation & purification ; RNA immunoprecipitation ; RNA U3
É parte de: Clinical and experimental immunology, 2001-11, Vol.126 (2), p.339-344
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: New antibodies against a U3 snRNP, which were named anti‐Myo 22/25 antibodies, were detected in four (8%) of 53 serum samples from patients with polymyositis/dermatomyositis (PM/DM) by RNA immunoprecipitation. In the protein immunoprecipitation analysis, all four serum samples precipitated 22 kDa and 25 kDa proteins, which were not precipitated by normal serum or serum positive for antifibrillarin antibodies. Three of the four PM/DM patients had other identified autoantibodies including anti‐PL‐12 antibodies, antihistone antibodies (AHA), anti‐SS‐A antibodies and anti‐SS‐B antibodies defined by double immunodiffusion, ELISA or RNA immunoprecipitation, although there were no significant correlations between anti‐Myo 22/25 antibodies and clinical or laboratory findings. There may be a subgroup of PM/DM patients whose sera are positive for anti‐Myo 22/25 antibodies.
Editor: Oxford, UK: Blackwell Science Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Prevalence in myositis of antibodies recognizing anti‐U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin

Kubo, M. ; Ihn, H. ; Kuwana, M. ; Yamane, K. ; Yazawa, N. ; Tamaki, K.

Oxford, UK: Blackwell Science Ltd

Buscando em bases de dados remotas. Favor aguardar.