skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

BDNF levels and liver stiffness in subjects with alcohol use disorder: Evaluation after alcohol withdrawal

Girard, Murielle ; Carrier, Paul ; Loustaud-Ratti, Véronique ; Nubukpo, Philippe

The American journal of drug and alcohol abuse, 2021-03, Vol.47 (2), p.191-198 [Periódico revisado por pares]

England: Taylor & Francis

Texto completo disponível

Citações Citado por
  • Título:
    BDNF levels and liver stiffness in subjects with alcohol use disorder: Evaluation after alcohol withdrawal
  • Autor: Girard, Murielle ; Carrier, Paul ; Loustaud-Ratti, Véronique ; Nubukpo, Philippe
  • Assuntos: Addictions ; Alcohol related disorders ; Alcohol use ; Alcohol use disorder ; Alcohol withdrawal ; Alcoholism ; BDNF ; Brain-derived neurotrophic factor ; Drinking behavior ; Homeostasis ; Life Sciences ; Liver ; liver fibrosis ; liver stiffness ; Santé publique et épidémiologie ; Serum ; Withdrawal symptoms
  • É parte de: The American journal of drug and alcohol abuse, 2021-03, Vol.47 (2), p.191-198
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: Background: Brain-derived neurotrophic factor (BDNF) plays a key role in the processes of withdrawal and addiction in alcohol use disorder (AUD), and is also involved in liver homeostasis. The role of BDNF in liver damage and its link with liver stiffness are not known. We hypothesize that serum BDNF levels are linked to changes in hepatic elasticity, both of which depend on variations in alcohol consumption. Objectives: We aimed to study the evolution of BDNF levels and changes in the liver stiffness (LS) of AUD subjects, within two months following withdrawal. Methods: We measured LS by FibroScan® (as an indicator of the degree of liver fibrosis), gamma glutamyl transferase (GGT) levels (as a nonspecific but sensitive marker of liver status) and serum BDNF levels of 62 alcohol-dependent subjects without previously identified liver complications. Measures were obtained at the time of withdrawal (M0) and two months later (M2). Results: BDNF levels increased after alcohol withdrawal and small variations of LS were observed. BDNF values increased significantly according to fibrosis stages measured by LS (p = .028 at M0), and were predicted by GGT levels in a regression model (p = .007 at M0 and p = .003 at M2). Conclusion: In AUD, BDNF levels were associated with measured LS when divided into fibrosis risk categories. Changes in LS and BDNF levels after alcohol withdrawal may be related to changes in homeostatic mechanisms, in addition to those of liver status.
  • Editor: England: Taylor & Francis
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.