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Axon Regeneration in the Mammalian Optic Nerve

Williams, Philip R ; Benowitz, Larry I ; Goldberg, Jeffrey L ; He, Zhigang

Annual review of vision science, 2020-09, Vol.6 (1), p.195-213 [Periódico revisado por pares]

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Título:
Axon Regeneration in the Mammalian Optic Nerve
Autor: Williams, Philip R ; Benowitz, Larry I ; Goldberg, Jeffrey L ; He, Zhigang
Assuntos: Animals ; axon regeneration ; Cell Survival ; Disease Models, Animal ; Humans ; KLF ; mTOR ; Nerve Crush ; Nerve Regeneration - physiology ; oncomodulin ; Optic Nerve Diseases ; Optic Nerve Injuries - physiopathology ; retinal ganglion cells ; Retinal Ganglion Cells - physiology ; survival
É parte de: Annual review of vision science, 2020-09, Vol.6 (1), p.195-213
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-2
Descrição: The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual functional defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as from optic glioma. By using optic nerve crush injury models, recent studies have revealed the cellular and molecular logic behind the regenerative failure of injured RGC axons in adult mammals and suggested several strategies with translational potential. This review summarizes these findings and discusses challenges for developing clinically applicable neural repair strategies.
Editor: United States: Annual Reviews
Idioma: Inglês

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