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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, Cathy E ; Perry, John RB ; Chasman, Daniel I ; He, Chunyan ; Lunetta, Kathryn L ; Visser, Jenny A ; Byrne, Enda M ; Cousminer, Diana L ; Gudbjartsson, Daniel F ; Feenstra, Bjarke ; Lin, Peng ; Mangino, Massimo ; Marongiu, Mara ; McArdle, Patrick F ; Stolk, Lisette ; van Wingerden, Sophie H ; Ingelsson, Erik ; Hayward, Caroline ; Magnusson, Patrik KE ; Warrington, Nicole M ; Zgaga, Lina ; Amin, Najaf ; Barroso, Inês ; Berenson, Gerald S ; Blackburn, Hannah ; Boerwinkle, Eric ; Buring, Julie E ; Chanock, Stephen J ; Chen, Wei ; Cornelis, Marilyn C ; Couper, David ; de Faire, Ulf ; de Geus, Eco JC ; Smith, George Davey ; Eiriksdottir, Gudny ; Garcia, Melissa ; Gasparini, Paolo ; Geller, Frank ; GIANT Consortium ; Hall, Per ; Hankinson, Susan E ; Hernandez, Dena G ; Hofman, Albert ; Illig, Thomas ; Järvelin, Marjo-Riitta ; Khaw, Kay-Tee ; Kilpeläinen, Tuomas O ; Kolcic, Ivana ; Launer, Lenore J ; Li, Shengxu ; Liu, Jianjun ; Levy, Daniel ; Melbye, Mads ; Mooser, Vincent ; Murray, Jeffrey C ; Murray, Sarah S ; Navarro, Pau ; Ness, Andrew R ; Northstone, Kate ; Oostra, Ben A ; Peacock, Munro ; Palmer, Lyle J ; Parker, Alex N ; Pedersen, Nancy L ; Peltonen, Leena ; Pharoah, Paul ; Plump, Andrew S ; Rafnar, Thorunn ; Rice, John P ; Rivadeneira, Fernando ; Rudan, Igor ; Sala, Cinzia ; Salomaa, Veikko ; Sanna, Serena ; Schork, Nicholas J ; Segrè, Ayellet V ; Shuldiner, Alan R ; Soranzo, Nicole ; Srinivasan, Sathanur R ; Strachan, David P ; Tammesoo, Mar-Liis ; Tikkanen, Emmi ; Toniolo, Daniela ; Tsui, Kim ; Tyrer, Jonathon ; van Dam, Rob M ; van Meurs, Joyce BJ ; Vollenweider, Peter ; Waeber, Gerard ; Waterworth, Dawn M ; Weedon, Michael N ; Wichmann, H Erich ; Willemsen, Gonneke ; Zhuang, Wei Vivian ; Boomsma, Dorret I ; Boyd, Heather A ; Demerath, Ellen W ; Loos, Ruth JF ; Uitterlinden, André G ; Murray, Anna

Nature genetics, 2010, Vol.42 (12), p.1077-1085 [Periódico revisado por pares]

Nature Research

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Título:
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Autor: Elks, Cathy E ; Perry, John RB ; Chasman, Daniel I ; He, Chunyan ; Lunetta, Kathryn L ; Visser, Jenny A ; Byrne, Enda M ; Cousminer, Diana L ; Gudbjartsson, Daniel F ; Feenstra, Bjarke ; Lin, Peng ; Mangino, Massimo ; Marongiu, Mara ; McArdle, Patrick F ; Stolk, Lisette ; van Wingerden, Sophie H ; Ingelsson, Erik ; Hayward, Caroline ; Magnusson, Patrik KE ; Warrington, Nicole M ; Zgaga, Lina ; Amin, Najaf ; Barroso, Inês ; Berenson, Gerald S ; Blackburn, Hannah ; Boerwinkle, Eric ; Buring, Julie E ; Chanock, Stephen J ; Chen, Wei ; Cornelis, Marilyn C ; Couper, David ; de Faire, Ulf ; de Geus, Eco JC ; Smith, George Davey ; Eiriksdottir, Gudny ; Garcia, Melissa ; Gasparini, Paolo ; Geller, Frank ; GIANT Consortium ; Hall, Per ; Hankinson, Susan E ; Hernandez, Dena G ; Hofman, Albert ; Illig, Thomas ; Järvelin, Marjo-Riitta ; Khaw, Kay-Tee ; Kilpeläinen, Tuomas O ; Kolcic, Ivana ; Launer, Lenore J ; Li, Shengxu ; Liu, Jianjun ; Levy, Daniel ; Melbye, Mads ; Mooser, Vincent ; Murray, Jeffrey C ; Murray, Sarah S ; Navarro, Pau ; Ness, Andrew R ; Northstone, Kate ; Oostra, Ben A ; Peacock, Munro ; Palmer, Lyle J ; Parker, Alex N ; Pedersen, Nancy L ; Peltonen, Leena ; Pharoah, Paul ; Plump, Andrew S ; Rafnar, Thorunn ; Rice, John P ; Rivadeneira, Fernando ; Rudan, Igor ; Sala, Cinzia ; Salomaa, Veikko ; Sanna, Serena ; Schork, Nicholas J ; Segrè, Ayellet V ; Shuldiner, Alan R ; Soranzo, Nicole ; Srinivasan, Sathanur R ; Strachan, David P ; Tammesoo, Mar-Liis ; Tikkanen, Emmi ; Toniolo, Daniela ; Tsui, Kim ; Tyrer, Jonathon ; van Dam, Rob M ; van Meurs, Joyce BJ ; Vollenweider, Peter ; Waeber, Gerard ; Waterworth, Dawn M ; Weedon, Michael N ; Wichmann, H Erich ; Willemsen, Gonneke ; Zhuang, Wei Vivian ; Boomsma, Dorret I ; Boyd, Heather A ; Demerath, Ellen W ; Loos, Ruth JF ; Uitterlinden, André G ; Murray, Anna
É parte de: Nature genetics, 2010, Vol.42 (12), p.1077-1085
Notas: Elks, Cathy E; Perry, John RB; Sulem, Patrick; Chasman, Daniel I; Franceschini, Nora; He, Chunyan; Lunetta, Kathryn L; Visser, Jenny A; Byrne, Enda M; Cousminer, Diana L; +165 more... Gudbjartsson, Daniel F; Esko, Tõnu; Feenstra, Bjarke; Hottenga, Jouke-Jan; Koller, Daniel L; Kutalik, Zoltán; Lin, Peng; Mangino, Massimo; Marongiu, Mara; McArdle, Patrick F; Smith, Albert V; Stolk, Lisette; van Wingerden, Sophie H; Zhao, Jing Hua; Albrecht, Eva; Corre, Tanguy; Ingelsson, Erik; Hayward, Caroline; Magnusson, Patrik KE; Smith, Erin N; Ulivi, Shelia; Warrington, Nicole M; Zgaga, Lina; Alavere, Helen; Amin, Najaf; Aspelund, Thor; Bandinelli, Stefania; Barroso, Inês; Berenson, Gerald S; Bergmann, Sven; Blackburn, Hannah; Boerwinkle, Eric; Buring, Julie E; Busonero, Fabio; Campbell, Harry; Chanock, Stephen J; Chen, Wei; Cornelis, Marilyn C; Couper, David; Coviello, Andrea D; d'Adamo, Pio; de Faire, Ulf; de Geus, Eco JC; Deloukas, Panos; Döring, Angela; Smith, George Davey; Easton, Douglas F; Eiriksdottir, Gudny; Emilsson, Valur; Eriksson, Johan; Ferrucci, Luigi; Folsom, Aaron R; Foroud, Tatiana; Garcia, Melissa; Gasparini, Paolo; Geller, Frank; Gieger, Christian; GIANT Consortium; Gudnason, Vilmundur; Hall, Per; Hankinson, Susan E; Ferreli, Liana; Heath, Andrew C; Hernandez, Dena G; Hofman, Albert; Hu, Frank B; Illig, Thomas; Järvelin, Marjo-Riitta; Johnson, Andrew D; Karasik, David; Khaw, Kay-Tee; Kiel, Douglas P; Kilpeläinen, Tuomas O; Kolcic, Ivana; Kraft, Peter; Launer, Lenore J; Laven, Joop SE; Li, Shengxu; Liu, Jianjun; Levy, Daniel; Martin, Nicholas G; McArdle, Wendy L; Melbye, Mads; Mooser, Vincent; Murray, Jeffrey C; Murray, Sarah S; Nalls, Michael A; Navarro, Pau; Nelis, Mari; Ness, Andrew R; Northstone, Kate; Oostra, Ben A; Peacock, Munro; Palmer, Lyle J; Palotie, Aarno; Paré, Guillaume; Parker, Alex N; Pedersen, Nancy L; Peltonen, Leena; Pennell, Craig E; Pharoah, Paul; Polasek, Ozren; Plump, Andrew S; Pouta, Anneli; Porcu, Eleonora; Rafnar, Thorunn; Rice, John P; Ring, Susan M; Rivadeneira, Fernando; Rudan, Igor; Sala, Cinzia; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schork, Nicholas J; Scuteri, Angelo; Segrè, Ayellet V; Shuldiner, Alan R; Soranzo, Nicole; Sovio, Ulla; Srinivasan, Sathanur R; Strachan, David P; Tammesoo, Mar-Liis; Tikkanen, Emmi; Toniolo, Daniela; Tsui, Kim; Tryggvadottir, Laufey; Tyrer, Jonathon; Uda, Manuela; van Dam, Rob M; van Meurs, Joyce BJ; Vollenweider, Peter; Waeber, Gerard; Wareham, Nicholas J; Waterworth, Dawn M; Weedon, Michael N; Wichmann, H Erich; Willemsen, Gonneke; Wilson, James F; Wright, Alan F; Young, Lauren; Zhai, Guangju; Zhuang, Wei Vivian; Bierut, Laura J; Boomsma, Dorret I; Boyd, Heather A; Crisponi, Laura; Demerath, Ellen W; van Duijn, Cornelia M; Econs, Michael J; Harris, Tamara B; Hunter, David J; Loos, Ruth JF; Metspalu, Andres; Montgomery, Grant W; Ridker, Paul M; Spector, Tim D; Streeten, Elizabeth A; Stefansson, Kari; Thorsteinsdottir, Unnur; Uitterlinden, André G; Widen, Elisabeth; Murabito, Joanne M; Ong, Ken K; Murray, Anna; (2010) Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature genetics, 42 (12). pp. 1077-1085. ISSN 1061-4036 DOI: https://doi.org/10.1038/ng.714
Descrição: To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10⁻⁶⁰) and 9q31.2 (P = 2.2 × 10⁻³³), we identified 30 new menarche loci (all P < 5 × 10⁻⁸) and found suggestive evidence for a further 10 loci (P < 1.9 × 10⁻⁶). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
Editor: Nature Research
Idioma: Inglês

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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