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Mitochondria as targets for cancer chemotherapy

Gogvadze, Vladimir ; Orrenius, Sten ; Zhivotovsky, Boris

Seminars in cancer biology, 2009-02, Vol.19 (1), p.57-66 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Mitochondria as targets for cancer chemotherapy
Autor: Gogvadze, Vladimir ; Orrenius, Sten ; Zhivotovsky, Boris
Assuntos: Adenosine Triphosphate - metabolism ; Animals ; Autophagy ; Calcium - metabolism ; Cell death ; Cell Death - physiology ; Energy Metabolism - physiology ; Glycolysis - physiology ; Hematology, Oncology and Palliative Medicine ; Humans ; Medicin och hälsovetenskap ; Mitochondria ; Mitochondria - drug effects ; Mitochondria - metabolism ; Mitochondrial Membranes - metabolism ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; Reactive Oxygen Species - metabolism ; Therapy ; Tumor ; Tumor Suppressor Protein p53 - metabolism ; Warburg effect
É parte de: Seminars in cancer biology, 2009-02, Vol.19 (1), p.57-66
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Abstract Heterogeneity of tumors dictates an individual approach to anticancer treatment. Despite their variability, almost all cancer cells demonstrate enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect, whereas mitochondrial activity in tumor cells is suppressed. Considering the key role of mitochondria in cell death, it appears that resistance of most tumors towards treatment can be, at least in part, explained by mitochondrial silencing in cancer cells. This review is devoted to the role of mitochondria in cell death, and describes how targeting of mitochondria can make tumor cells more susceptible to anticancer treatment.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Mitochondria as targets for cancer chemotherapy

Gogvadze, Vladimir ; Orrenius, Sten ; Zhivotovsky, Boris

England: Elsevier Ltd

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