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Combining nano-physical and computational investigations to understand the nature of "aging" in dermal collagen

Ahmed, Tarek ; Nash, Anthony ; Clark, Kristina En ; Ghibaudo, Marion ; de Leeuw, Nora H ; Potter, Anne ; Stratton, Richard ; Birch, Helen L ; Enea Casse, Ramona ; Bozec, Laurent

International journal of nanomedicine, 2017-01, Vol.12, p.3303-3314 [Periódico revisado por pares]

New Zealand: Dove Medical Press Limited

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Título:
Combining nano-physical and computational investigations to understand the nature of "aging" in dermal collagen
Autor: Ahmed, Tarek ; Nash, Anthony ; Clark, Kristina En ; Ghibaudo, Marion ; de Leeuw, Nora H ; Potter, Anne ; Stratton, Richard ; Birch, Helen L ; Enea Casse, Ramona ; Bozec, Laurent
Assuntos: Adult ; Advanced Glycation End Products ; Age ; Aged ; Aged, 80 and over ; Ageing ; Aging ; Aging - physiology ; Atomic Force Microscopy ; Biomechanical Phenomena ; Collagen ; Collagen - chemistry ; Collagen - physiology ; Collagen - ultrastructure ; Dermis - physiology ; Dermis - ultrastructure ; Elastic Modulus ; Extracellular matrix ; Extracellular Matrix - physiology ; Female ; Fibroblasts ; Glycation End Products, Advanced - chemistry ; Glycation End Products, Advanced - metabolism ; Homeostasis ; Humans ; Hydration ; Investigations ; Male ; Mechanical properties ; Microscopy, Atomic Force ; Models, Theoretical ; Nanomechanics ; Nanotechnology ; Original Research ; Physiological aspects ; Skin ; University colleges ; Water - chemistry
É parte de: International journal of nanomedicine, 2017-01, Vol.12, p.3303-3314
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The extracellular matrix of the dermis is a complex, dynamic system with the various dermal components undergoing individual physiologic changes as we age. Age-related changes in the physical properties of collagen were investigated in particular by measuring the effect of aging, most likely due to the accumulation of advanced glycation end product (AGE) cross-links, on the nanomechanical properties of the collagen fibril using atomic force microscope nano-indentation. An age-related decrease in the Young's modulus of the transverse fibril was observed (from 8.11 to 4.19 GPa in young to old volunteers, respectively, <0.001). It is proposed that this is due to a change in the fibril density caused by age-related differences in water retention within the fibrils. The new collagen-water interaction mechanism was verified by electronic structure calculations, showing it to be energetically feasible.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglês

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Combining nano-physical and computational investigations to understand the nature of "aging" in dermal collagen

Ahmed, Tarek ; Nash, Anthony ; Clark, Kristina En ; Ghibaudo, Marion ; de Leeuw, Nora H ; Potter, Anne ; Stratton, Richard ; Birch, Helen L ; Enea Casse, Ramona ; Bozec, Laurent

New Zealand: Dove Medical Press Limited

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