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Ovalbumin Gene: Evidence for a Leader Sequence in mRNA and DNA Sequences at the Exon-Intron Boundaries

Breathnach, R. ; Benoist, C. ; O'Hare, K. ; Gannon, F. ; Chambon, P.

Proceedings of the National Academy of Sciences - PNAS, 1978-10, Vol.75 (10), p.4853-4857 [Periódico revisado por pares]

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Título:
Ovalbumin Gene: Evidence for a Leader Sequence in mRNA and DNA Sequences at the Exon-Intron Boundaries
Autor: Breathnach, R. ; Benoist, C. ; O'Hare, K. ; Gannon, F. ; Chambon, P.
Assuntos: Animals ; Base Sequence ; Chickens - genetics ; DNA ; Enzymes ; Exons ; Genes ; Genomes ; Introns ; Messenger RNA ; Nucleotide sequences ; Nucleotides ; Ovalbumin - genetics ; RNA, Messenger ; Splicing
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1978-10, Vol.75 (10), p.4853-4857
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Selected regions of cloned EcoRI fragments of the chicken ovalbumin gene have been sequenced. The positions where the sequences coding for ovalbumin mRNA (ov-mRNA) are interrupted in the genome have been determined, and a previously unreported interruption in the DNA sequences coding for the 5′nontranslated region of the messenger has been discovered. Because directly repeated sequences are found at exon-intron boundaries, the nucleotide sequence alone cannot define unique excision-ligation points for the processing of a possible ov-mRNA precursor. However, the sequences in these boundary regions share common features; this leads to the proposal that there are, in fact, unique excision-ligation points common to all boundaries.
Editor: United States: National Academy of Sciences of the United States of America
Idioma: Inglês

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