Verification of the seizure liability of compounds based on their in vitro functional activity in cultured rat cortical neurons and co-cultured human iPSC-derived neurons with astrocytes and in vivo extrapolation to cerebrospinal fluid concentration

Ishibashi, Y. ; Nagafuku, N. ; Kinoshita, K. ; Okamura, A. ; Shirakawa, T. ; Suzuki, I.

Toxicology and applied pharmacology, 2023-10, Vol.476, p.116675-116675, Article 116675 [Periódico revisado por pares]

Elsevier Inc

Texto completo disponível