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The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with γ-radiation-induced T-cell lymphoblastic lymphomas

SANTOS, J ; GONZALEZ-SANCHEZ, L ; MONTAGUTELLI, X ; FERNANDEZ-PIQUERAS, J ; VILLA-MORALES, M ; ORS, I ; LOPEZ-NIEVA, P ; VAQUERO, C ; GONZALEZ-GUGEL, E ; FERNANDEZ-NAVARRO, P ; RONCERO, A. M ; GUENET, J.-L

Oncogene, 2010-09, Vol.29 (38), p.5265-5273 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with γ-radiation-induced T-cell lymphoblastic lymphomas
Autor: SANTOS, J ; GONZALEZ-SANCHEZ, L ; MONTAGUTELLI, X ; FERNANDEZ-PIQUERAS, J ; VILLA-MORALES, M ; ORS, I ; LOPEZ-NIEVA, P ; VAQUERO, C ; GONZALEZ-GUGEL, E ; FERNANDEZ-NAVARRO, P ; RONCERO, A. M ; GUENET, J.-L
Assuntos: Animals ; Apoptosis ; B7-1 Antigen - genetics ; B7-H1 Antigen ; Biological and medical sciences ; Cancer ; Care and treatment ; Cell physiology ; Cell survival ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chromosome 19 ; Coevolution ; Complementary DNA ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Haplotypes ; Hematologic and hematopoietic diseases ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocytes T ; Lymphoma ; Lymphoma, T-Cell - genetics ; Lymphoma, T-Cell - pathology ; Medical sciences ; Membrane Glycoproteins - genetics ; Mice ; Mice, Inbred C57BL ; Microenvironments ; Molecular and cellular biology ; Neoplasms, Radiation-Induced - genetics ; Neoplasms, Radiation-Induced - pathology ; Non-Hodgkin's lymphomas ; Nucleotide sequence ; Peptides - genetics ; Polymorphism, Genetic ; Radiation ; Staphylococcal enterotoxin G ; Stromal cells ; Survival Analysis ; T cell lymphoma ; T cell receptors ; Thymus ; Tumors ; γ Radiation
É parte de: Oncogene, 2010-09, Vol.29 (38), p.5265-5273
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SourceType-Scholarly Journals-1
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Descrição: Using an inter-specific subcongenic strain, Nested Recombinant Haplotype 3 (NRH3), generated between two mouse strains showing extreme differences in γ-radiation-induced thymic lymphoma susceptibility (SEG/Pas and C57BL/6J), we have identified a critical region on chromosome 19 that regulates survival of mice suffering from T-cell lymphoblastic lymphomas. Mapped on this region, the gene encoding the Cd274 ligand is able to trigger an inhibitory effect that modulates T-cell receptor (TCR) signalling and affects thymocyte maturation. Interestingly, this gene shows differential expression between thymic stromal cells from both strains in early response to a single sublethal γ-ray dose, but is inhibited in T-cell lymphoblastic lymphomas. Furthermore, we have identified several polymorphisms in the complementary DNA sequence of this gene that affect the affinity for its Cd279 receptor and are able to induce a differential rate of thymocyte apoptosis. Taken together, our data are consistent with Cd274 acting as a genetic modifier that influences the survival of γ-radiation-induced T-cell lymphoma-bearing mice. The data similarly support the idea of a co-evolution of tumour cells and associated stromal cells to generate a favourable microenvironment for T-cell lymphoma growth.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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The stromal gene encoding the CD274 antigen as a genetic modifier controlling survival of mice with γ-radiation-induced T-cell lymphoblastic lymphomas

SANTOS, J ; GONZALEZ-SANCHEZ, L ; MONTAGUTELLI, X ; FERNANDEZ-PIQUERAS, J ; VILLA-MORALES, M ; ORS, I ; LOPEZ-NIEVA, P ; VAQUERO, C ; GONZALEZ-GUGEL, E ; FERNANDEZ-NAVARRO, P ; RONCERO, A. M ; GUENET, J.-L

Basingstoke: Nature Publishing Group

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