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Selection signature analysis implicates the PC1/PCSK1 region for chicken abdominal fat content

Zhang, Hui ; Hu, Xiaoxiang ; Wang, Zhipeng ; Zhang, Yuandan ; Wang, Shouzhi ; Wang, Ning ; Ma, Li ; Leng, Li ; Wang, Shengwen ; Wang, Qigui ; Wang, Yuxiang ; Tang, Zhiquan ; Li, Ning ; Da, Yang ; Li, Hui Androulakis, Ioannis P.

PloS one, 2012-07, Vol.7 (7), p.e40736-e40736 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Selection signature analysis implicates the PC1/PCSK1 region for chicken abdominal fat content
Autor: Zhang, Hui ; Hu, Xiaoxiang ; Wang, Zhipeng ; Zhang, Yuandan ; Wang, Shouzhi ; Wang, Ning ; Ma, Li ; Leng, Li ; Wang, Shengwen ; Wang, Qigui ; Wang, Yuxiang ; Tang, Zhiquan ; Li, Ning ; Da, Yang ; Li, Hui
Androulakis, Ioannis P.
Assuntos: Abdomen ; Abdominal Fat - metabolism ; Agriculture ; Alleles ; Analysis ; Animal sciences ; Animals ; Association analysis ; Base Sequence ; Bioinformatics ; Biology ; Body composition ; Chickens - genetics ; Chickens - metabolism ; Chromosome Mapping ; Chromosomes ; Gene Frequency ; Genes ; Genetic aspects ; Genetics ; Genome ; Genome-Wide Association Study ; Genomes ; Genomics ; Genotype ; Growth factors ; Haplotypes ; Heterozygosity ; Homozygosity ; Insulin-like growth factor I ; Laboratory animals ; Linkage Disequilibrium ; Markers ; Meat processing ; Metabolism ; Obesity ; Phenotype ; Polymorphism, Single Nucleotide ; Population ; Poultry ; Proprotein Convertase 1 - genetics ; Signature analysis ; Signatures ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Studies ; Veterinary Science ; Web sites ; Z chromosomes ; Zoology
É parte de: PloS one, 2012-07, Vol.7 (7), p.e40736-e40736
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: HL YZ NL. Performed the experiments: HZ ZW Shouzhi Wang NW QW HL. Analyzed the data: HZ XH LM Shengwen Wang YD. Contributed reagents/materials/analysis tools: YW LL XH ZT. Wrote the paper: HZ ZW YD HL.
Descrição: We conducted a selection signature analysis using the chicken 60k SNP chip in two chicken lines that had been divergently selected for abdominal fat content (AFC) for 11 generations. The selection signature analysis used multiple signals of selection, including long-range allele frequency differences between the lean and fat lines, long-range heterozygosity changes, linkage disequilibrium, haplotype frequencies, and extended haplotype homozygosity. Multiple signals of selection identified ten signatures on chromosomes 1, 2, 4, 5, 11, 15, 20, 26 and Z. The 0.73 Mb PC1/PCSK1 region of the Z chromosome at 55.43-56.16 Mb was the most heavily selected region. This region had 26 SNP markers and seven genes, Mar-03, SLC12A2, FBN2, ERAP1, CAST, PC1/PCSK1 and ELL2, where PC1/PCSK1 are the chicken/human names for the same gene. The lean and fat lines had two main haplotypes with completely opposite SNP alleles for the 26 SNP markers and were virtually line-specific, and had a recombinant haplotype with nearly equal frequency (0.193 and 0.196) in both lines. Other haplotypes in this region had negligible frequencies. Nine other regions with selection signatures were PAH-IGF1, TRPC4, GJD4-CCNY, NDST4, NOVA1, GALNT9, the ESRP2-GALR1 region with five genes, the SYCP2-CADH4 with six genes, and the TULP1-KIF21B with 14 genes. Genome-wide association analysis showed that nearly all regions with evidence of selection signature had SNP effects with genome-wide significance (P<10(-6)) on abdominal fat weight and percentage. The results of this study provide specific gene targets for the control of chicken AFC and a potential model of AFC in human obesity.
Editor: United States: Public Library of Science
Idioma: Inglês

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Selection signature analysis implicates the PC1/PCSK1 region for chicken abdominal fat content

Zhang, Hui ; Hu, Xiaoxiang ; Wang, Zhipeng ; Zhang, Yuandan ; Wang, Shouzhi ; Wang, Ning ; Ma, Li ; Leng, Li ; Wang, Shengwen ; Wang, Qigui ; Wang, Yuxiang ; Tang, Zhiquan ; Li, Ning ; Da, Yang ; Li, Hui Androulakis, Ioannis P.

United States: Public Library of Science

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