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Concise Review: Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications

Loukogeorgakis, Stavros P. ; De Coppi, Paolo

Stem cells (Dayton, Ohio), 2017-07, Vol.35 (7), p.1663-1673 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Concise Review: Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications
Autor: Loukogeorgakis, Stavros P. ; De Coppi, Paolo
Assuntos: Amniocentesis ; Amniotic fluid ; Amniotic Fluid - cytology ; Amniotic Fluid - metabolism ; Amniotic fluid stem cell ; Animals ; Biomarkers - metabolism ; c-Kit protein ; Cell Differentiation ; Cell Lineage - physiology ; Cell Proliferation ; Cell therapy ; Cell transplantation ; Disease Models, Animal ; Embryo cells ; Embryos ; Ethics ; Fetal stem cell ; Fetus ; Gene Expression ; Gestational Age ; Humans ; Immunomodulation ; Inflammatory diseases ; Medicine ; Octamer Transcription Factor-3 - genetics ; Octamer Transcription Factor-3 - metabolism ; Organs ; Proto-Oncogene Proteins c-kit - genetics ; Proto-Oncogene Proteins c-kit - metabolism ; Proto-Oncogene Proteins c-myc - genetics ; Proto-Oncogene Proteins c-myc - metabolism ; Regeneration (physiology) ; Regenerative medicine ; Regenerative Medicine - methods ; Stem Cell Transplantation ; Stem cells ; Stem Cells - cytology ; Stem Cells - physiology ; Tissue engineering ; Transplantation ; Tumors
É parte de: Stem cells (Dayton, Ohio), 2017-07, Vol.35 (7), p.1663-1673
Notas: Available online without subscription through the open access option
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Descrição: The amniotic fluid has been identified as an untapped source of cells with broad potential, which possess immunomodulatory properties and do not have the ethical and legal limitations of embryonic stem cells. CD117(c‐Kit)+ cells selected from amniotic fluid have been shown to differentiate into cell lineages representing all three embryonic germ layers without generating tumors, making them ideal candidates for regenerative medicine applications. Moreover, their ability to engraft in injured organs and modulate immune and repair responses of host tissues, suggest that transplantation of such cells may be useful for the treatment of various degenerative and inflammatory diseases. Although significant questions remain regarding the origin, heterogeneous phenotype, and expansion potential of amniotic fluid stem cells, evidence to date supports their potential role as a valuable stem cell source for the field of regenerative medicine. Stem Cells 2017;35:1663–1673
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Concise Review: Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications

Loukogeorgakis, Stavros P. ; De Coppi, Paolo

United States: Wiley Subscription Services, Inc

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