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ACDC/Adiponectin and PPAR-[gamma] Gene Polymorphisms: Implications for Features of Obesity [Erratum: 2006 May, v. 14, no. 5, p. 928.]

Tanko, Laszlo B ; Siddiq, Afshan ; Lecoeur, Cecile ; Larsen, Philip J ; Christiansen, Claus ; Walley, Andrew ; Froguel, Philippe

Obesity research, 2005-12, Vol.13 (12), p.2113-2121

Baton Rouge: Blackwell Publishing Ltd

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  • Título:
    ACDC/Adiponectin and PPAR-[gamma] Gene Polymorphisms: Implications for Features of Obesity [Erratum: 2006 May, v. 14, no. 5, p. 928.]
  • Autor: Tanko, Laszlo B ; Siddiq, Afshan ; Lecoeur, Cecile ; Larsen, Philip J ; Christiansen, Claus ; Walley, Andrew ; Froguel, Philippe
  • Assuntos: adipocytes ; adiponectin ; alleles ; body composition ; body fat distribution ; elderly ; genes ; genetic polymorphism ; genetic variation ; genotype ; haplotypes ; hormones ; insulin resistance ; molecular sequence data ; obesity ; promoter regions ; single nucleotide polymorphism ; women
  • É parte de: Obesity research, 2005-12, Vol.13 (12), p.2113-2121
  • Descrição: OBJECTIVE: The main purpose of this study was to investigate associations of single-nucleotide polymorphisms (SNPs) in the adipocyte C1q and collagen domain-containing (ACDC) gene and its regulator, the nuclear peroxisome proliferator-activated receptor (PPAR)-[gamma] gene, with body fat mass and its topographical distribution in postmenopausal women. RESEARCH METHODS AND PROCEDURES: Participants were 1501 healthy women, 60 to 85 years old, who were genotyped for four SNPs in the ACDC gene (-11391G/A, -11377C/G, +45T/G, +276G/T) and the Pro12Ala SNP in the PPAR-[gamma] gene. Total body fat mass and the central to peripheral fat mass ratio (CFM/PFM ratio) were measured using DXA. Adiponectin and homeostasis model assessment of insulin resistance were measured in 287 subjects. RESULTS: The -11377C/G SNP was associated with adiponectin (p < 0.001) and the CFM/PFM ratio (p = 0.005); the G allele being associated with low adiponectin and high CFM/PFM ratio. Similar associations of adiponectin (p = 0.0001) and the CFM/PFM ratio (p = 0.002) characterized the 1_2 (G_G) promoter haplotype (11391G/A_-11377C/G). Genotype variation of SNP Pro12Ala was associated with total body fat mass (p = 0.04); women with GG being the most obese (p = 0.01). The Ala/Ala (GG) genotype of Pro12Ala SNP interacted with the CC genotype of SNP-11377C/G in the determination of BMI (p = 0.001), when analyzed using a codominant model. DISCUSSION: Polymorphisms in the ACDC gene are associated with body fat distribution, whereas the Pro12Ala polymorphism in PPAR-[gamma] is associated with overall adiposity, apparently in interaction with an ACDC promoter SNP.
  • Editor: Baton Rouge: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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