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Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers

DeKosky, Steven T ; Blennow, Kaj ; Ikonomovic, Milos D ; Gandy, Sam

Nature reviews. Neurology, 2013-04, Vol.9 (4), p.192-200 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers
Autor: DeKosky, Steven T ; Blennow, Kaj ; Ikonomovic, Milos D ; Gandy, Sam
Assuntos: Biological Markers ; Biomarkers - metabolism ; Brain ; Brain - metabolism ; Brain - pathology ; Brain Injuries ; Brain Injuries - complications ; Brain Injuries - etiology ; Brain Injuries - metabolism ; Brain Injury ; Brain Injury, Chronic - diagnosis ; Brain Injury, Chronic - etiology ; Brain Injury, Chronic - metabolism ; Brain research ; Care and treatment ; Chronic ; Chronic brain injury ; Chronic Disease ; Chronic traumatic encephalopathy ; classification ; complications ; Development and progression ; diagnosis ; etiology ; Humans ; metabolism ; Nervous System Diseases ; Nervous System Diseases - classification ; Nervous System Diseases - etiology ; Neuroimaging ; Neurosciences ; Neurovetenskaper ; pathology
É parte de: Nature reviews. Neurology, 2013-04, Vol.9 (4), p.192-200
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Descrição: Over the past decade, public awareness of the long-term pathological consequences of traumatic brain injury (TBI) has increased. Such awareness has been stimulated mainly by reports of progressive neurological dysfunction in athletes exposed to repetitive concussions in high-impact sports such as boxing and American football, and by the rising number of TBIs in war veterans who are now more likely to survive explosive blasts owing to improved treatment. Moreover, the entity of chronic traumatic encephalopathy (CTE)--which is marked by prominent neuropsychiatric features including dementia, parkinsonism, depression, agitation, psychosis, and aggression--has become increasingly recognized as a potential late outcome of repetitive TBI. Annually, about 1% of the population in developed countries experiences a clinically relevant TBI. The goal of this Review is to provide an overview of the latest understanding of CTE pathophysiology, and to delineate the key issues that are challenging clinical and research communities, such as accurate quantification of the risk of CTE, and development of reliable biomarkers for single-incident TBI and CTE.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers

DeKosky, Steven T ; Blennow, Kaj ; Ikonomovic, Milos D ; Gandy, Sam

England: Nature Publishing Group

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