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Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine

Diaz-San Segundo, Fayna ; Dias, Camila C ; Moraes, Mauro P ; Weiss, Marcelo ; Perez-Martin, Eva ; Salazar, Andres M ; Grubman, Marvin J ; de los Santos, Teresa

Virology (New York, N.Y.), 2014-11, Vol.468 (C), p.283-292 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine
Autor: Diaz-San Segundo, Fayna ; Dias, Camila C ; Moraes, Mauro P ; Weiss, Marcelo ; Perez-Martin, Eva ; Salazar, Andres M ; Grubman, Marvin J ; de los Santos, Teresa
Assuntos: Adenoviruses, Human ; Adjuvants ; Animals ; Antibodies, Neutralizing ; Antibodies, Viral - blood ; Carboxymethylcellulose Sodium - analogs & derivatives ; Carboxymethylcellulose Sodium - pharmacology ; Cell-mediated immunity ; Foot-and-mouth disease ; Foot-and-Mouth Disease - prevention & control ; Foot-and-mouth disease virus ; Genetic Vectors ; HEK293 Cells ; Human adenovirus ; Human adenovirus 5 ; Humans ; Infectious Disease ; Neutralizing antibodies ; Poly I-C - pharmacology ; Poly ICLC ; Polylysine - analogs & derivatives ; Polylysine - pharmacology ; Replication-defective adenovirus ; Swine ; Swine Diseases - prevention & control ; Vaccines ; Viral Vaccines - immunology ; Virus Replication
É parte de: Virology (New York, N.Y.), 2014-11, Vol.468 (C), p.283-292
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ObjectType-Article-1
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USDOE
1940-32000-057-00D
Descrição: Abstract Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. We have previously demonstrated that a replication-defective human adenovirus 5 vector carrying the FMDV capsid coding region of serotype A24 Cruzeiro (Ad5-CI-A24-2B) protects swine and cattle against FMDV challenge by 7 days post-vaccination. However, since relatively large amounts of Ad5-CI-A24-2B are required to induce protection this strategy could be costly for livestock production. Poly ICLC is a synthetic double stranded RNA that activates multiple innate and adaptive immune pathways. In this study, we have tested for the first time, the adjuvant effect of poly ICLC in combination with Ad5-CI-A24-2B in swine. We found that the combination resulted in a reduction of the vaccine protective dose by 80-fold. Interestingly, the lowest dose of Ad5-CI-A24-2B plus 1 mg of poly ICLC protected animals against challenge even in the absence of detectable FMDV-specific neutralizing antibodies at the time of challenge.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine

Diaz-San Segundo, Fayna ; Dias, Camila C ; Moraes, Mauro P ; Weiss, Marcelo ; Perez-Martin, Eva ; Salazar, Andres M ; Grubman, Marvin J ; de los Santos, Teresa

United States: Elsevier Inc

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