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Prognostic Value of Vitamin D Level for All-cause Mortality, and Association With Inflammatory Markers, in HIV-infected Persons

Shepherd, Leah ; Souberbielle, Jean-Claude ; Bastard, Jean-Philippe ; Fellahi, Soraya ; Capeau, Jaqueline ; Reekie, Joanne ; Reiss, Peter ; Blaxhult, Anders ; Bickel, Markus ; Leen, Clifford ; Kirk, Ole ; Lundgren, Jens D. ; Mocroft, Amanda ; Viard, Jean-Paul

The Journal of infectious diseases, 2014-07, Vol.210 (2), p.234-243 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Prognostic Value of Vitamin D Level for All-cause Mortality, and Association With Inflammatory Markers, in HIV-infected Persons
Autor: Shepherd, Leah ; Souberbielle, Jean-Claude ; Bastard, Jean-Philippe ; Fellahi, Soraya ; Capeau, Jaqueline ; Reekie, Joanne ; Reiss, Peter ; Blaxhult, Anders ; Bickel, Markus ; Leen, Clifford ; Kirk, Ole ; Lundgren, Jens D. ; Mocroft, Amanda ; Viard, Jean-Paul
Assuntos: Adult ; AIDS ; Antiretrovirals ; Antivirals ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Cohort Studies ; Disease Progression ; Female ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV infections ; HIV Infections - diagnosis ; HIV Infections - immunology ; HIV Infections - mortality ; HIV Infections - pathology ; HIV/AIDS ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Inflammation ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Microbiology ; Middle Aged ; Prognosis ; Prospective Studies ; Survival Analysis ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Vitamin D ; Vitamin D - blood ; Vitamin D deficiency
É parte de: The Journal of infectious diseases, 2014-07, Vol.210 (2), p.234-243
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Descrição: Background. Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH) D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers. Methods. Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH) D levels and immunological/inflammatory markers. Results. In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P= .04) for a 2-fold increase in latest 25(OH) D level. There was no association between 25(OH) D and the occurrence of AIDS or non-AIDS-defining events (P >.05). In patients with current 25(OH) D < 10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P =.04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P =.76). Conclusions. Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Prognostic Value of Vitamin D Level for All-cause Mortality, and Association With Inflammatory Markers, in HIV-infected Persons

Shepherd, Leah ; Souberbielle, Jean-Claude ; Bastard, Jean-Philippe ; Fellahi, Soraya ; Capeau, Jaqueline ; Reekie, Joanne ; Reiss, Peter ; Blaxhult, Anders ; Bickel, Markus ; Leen, Clifford ; Kirk, Ole ; Lundgren, Jens D. ; Mocroft, Amanda ; Viard, Jean-Paul

Oxford: Oxford University Press

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