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Pathogenesis of gammaherpesvirus infections

Ackermann, Mathias

Veterinary microbiology, 2006-03, Vol.113 (3), p.211-222 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Pathogenesis of gammaherpesvirus infections
Autor: Ackermann, Mathias
Assuntos: Alcelaphine herpesvirus 1 ; animal diseases ; Animals ; Bovine herpesvirus 4 ; disease reservoirs ; Disease Reservoirs - veterinary ; Disease Reservoirs - virology ; disease transmission ; Epstein-Barr virus ; Equine herpesvirus ; Gammaherpesvirinae - genetics ; Gammaherpesvirinae - pathogenicity ; Gammaherpesvirus ; Gammaherpesviruses ; gene expression ; Gene Expression Regulation, Viral ; Herpesviridae Infections - veterinary ; Herpesviridae Infections - virology ; Herpesvirus ; host range ; human diseases ; Human herpesvirus 8 ; immune response ; latent infections ; latent period ; literature reviews ; Lymphocryptovirus ; microbial genetics ; Murine herpesvirus ; Ovine herpesvirus 2 ; pathogen shedding ; Pathogenesis ; Review ; Rhadinovirus ; Species Specificity ; viral diseases of animals and humans ; viral proteins ; Virus Latency - genetics
É parte de: Veterinary microbiology, 2006-03, Vol.113 (3), p.211-222
Notas: http://dx.doi.org/10.1016/j.vetmic.2005.11.008
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Descrição: Gammaherpesviruses are members of an emerging subfamily among the Herpesviridae. Two genera are discriminated: (i) lymphocryptovirus, including its type species Epstein-Barr virus (EBV), and (ii) rhadinovirus, including viruses of interest for medicine, veterinary medicine, and biomedical research, i.e. alcelaphine herpesvirus 1, bovine herpesvirus 4, equine herpesvirus 2, human herpesvirus 8, mouse herpesvirus 68, and ovine herpesvirus 2 (OvHV-2). The perception that these viruses have a narrow host range is misleading, since they cover a surprisingly wide host range, both on the cellular and the organism's level. For example, the natural range of OvHV-2 infection extends over a common animal order. While the host range determinants of EBV are well known, the corresponding features of the rhadinoviruses need still to be defined. Similarly, the gene expression patterns of the veterinary rhadinoviruses during latency require further characterization. In vivo, the gammaherpesviruses have evolved to actively protect their latently infected cells from being destroyed by immune functions of their native host. In return, those reservoir hosts have evolved to being infected and transmit the virus without overt disease symptoms. However, a balanced immune response needs to be in control over the number of infected cells. Virus excretion is usually at low level and may occur either constantly or intermittently. Animal species that are targeted by the virus but did not participate in the process of co-evolution as well as hosts with immune deficiencies are known to loose control over the amount of latently infected cells, which results in the development of lethal diseases, such as malignant catarrhal fever or Kaposi's sarcoma.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Pathogenesis of gammaherpesvirus infections

Ackermann, Mathias

Netherlands: Elsevier B.V

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