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Immunological exhaustion: How to make a disparate concept operational?

Kaminski, Hannah ; Lemoine, Maël ; Pradeu, Thomas LeibundGut-Landmann, Salomé

PLoS pathogens, 2021-09, Vol.17 (9), p.e1009892-e1009892 [Periódico revisado por pares]

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Título:
Immunological exhaustion: How to make a disparate concept operational?
Autor: Kaminski, Hannah ; Lemoine, Maël ; Pradeu, Thomas
LeibundGut-Landmann, Salomé
Assuntos: Antigens ; Apoptosis ; Biology and Life Sciences ; Cancer ; Cellular control mechanisms ; Coronaviruses ; COVID-19 ; Cytokines ; Cytotoxicity ; Development and progression ; Health aspects ; Hepatitis ; History, Philosophy and Sociology of Sciences ; Humanities and Social Sciences ; Immune response ; Immunological research ; Immunology ; Infection ; Infections ; Life Sciences ; Lymphocytes ; Medicine and Health Sciences ; Regulation ; Review ; Therapeutic applications ; Viral infections
É parte de: PLoS pathogens, 2021-09, Vol.17 (9), p.e1009892-e1009892
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
The authors have declared that no competing interests exist.
Descrição: In this essay, we show that 3 distinct approaches to immunological exhaustion coexist and that they only partially overlap, generating potential misunderstandings. Exploring cases ranging from viral infections to cancer, we propose that it is crucial, for experimental and therapeutic purposes, to clarify these approaches and their interconnections so as to make the concept of exhaustion genuinely operational.
Editor: San Francisco: Public Library of Science
Idioma: Inglês

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