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In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra

Cheng, H.Y ; Lin, T.C ; Ishimaru, K ; Yang, C.M ; Wang, K.C ; Lin, C.C

Planta medica, 2003-10, Vol.69 (10), p.953-956 [Periódico revisado por pares]

Stuttgart: Thieme

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Título:
In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra
Autor: Cheng, H.Y ; Lin, T.C ; Ishimaru, K ; Yang, C.M ; Wang, K.C ; Lin, C.C
Assuntos: Animals ; anthocyanins ; Anthocyanins - administration & dosage ; Anthocyanins - pharmacology ; Anthocyanins - therapeutic use ; Antiviral Agents - administration & dosage ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; antiviral properties ; Biological and medical sciences ; cell lines ; Cercopithecus aethiops ; chemical structure ; cultured cells ; cytotoxicity ; General pharmacology ; Herpesvirus 2, Human - drug effects ; human health ; Human herpesvirus 2 ; humans ; in vitro studies ; Inhibitory Concentration 50 ; Letter ; Medical sciences ; medicinal plants ; monkeys ; Myrica ; Myrica rubra ; Myricaceae ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Bark ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; prodelphinidin B-2 3,3'-di-O-gallate ; Vero Cells - virology
É parte de: Planta medica, 2003-10, Vol.69 (10), p.953-956
Descrição: Abstract In this study, the IN VITRO antiviral properties of prodelphinidin B-2 3,3′-di-O-gallate (PB233′OG) isolated from the bark of MYRICA RUBRA (Myricaceae) was investigated. Results showed that PB233′OG exhibited anti-herpes simplex virus type 2 (HSV-2) activity with IC 50 values of 5.3 ± 0.1 and 0.4 ± 0.04 μM for XTT and plaque reduction assays, respectively. The IC 50 value increased with increasing MOI (multiplicity of infection). PB233′OG did not show a cellular cytotoxic effect at concentrations that possessed antiviral activity. Mechanistic studies demonstrated that PB233′OG inhibited HSV-2 attachment to the Vero cell, interfered with the penetration of HSV-2 into the Vero cell, affected the late stage(s) of the HSV-2 infection cycle, and also reduced the viral infectivity at high concentrations. It is concluded that PB233′OG exhibits various modes of action in its anti-HSV-2 effects.
Editor: Stuttgart: Thieme
Idioma: Inglês

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In vitro antiviral activity of prodelphinidin B-2 3,3'-di-O-gallate from Myrica rubra

Cheng, H.Y ; Lin, T.C ; Ishimaru, K ; Yang, C.M ; Wang, K.C ; Lin, C.C

Stuttgart: Thieme

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