Idioma:

Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms

Miller, Lloyd S ; Fowler, Vance G ; Shukla, Sanjay K ; Rose, Warren E ; Proctor, Richard A

FEMS microbiology reviews, 2020-01, Vol.44 (1), p.123-153 [Periódico revisado por pares]

England: Oxford University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms
Autor: Miller, Lloyd S ; Fowler, Vance G ; Shukla, Sanjay K ; Rose, Warren E ; Proctor, Richard A
Assuntos: Antibiotic resistance ; Antibiotics ; Antibodies ; Antigens ; Bacteria ; Bacterial genetics ; Bacterial Toxins - metabolism ; Bacterial Vaccines - immunology ; Bacterial Vaccines - standards ; Clinical trials ; Drug resistance ; Drug resistance in microorganisms ; Genetic factors ; Genetics ; Health aspects ; Health risks ; Humans ; Immune clearance ; Immune response ; Immunotherapy ; Infection ; Infections ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - immunology ; Methicillin-Resistant Staphylococcus aureus - pathogenicity ; Morbidity ; Multidrug resistance ; Neutralization ; Opsonophagocytosis ; Penicillin ; Pore formation ; Prevention ; Public health ; Review ; Staphylococcal infections ; Staphylococcal Infections - immunology ; Staphylococcal Infections - prevention & control ; Staphylococcus aureus ; Staphylococcus aureus - genetics ; Staphylococcus aureus - immunology ; Staphylococcus aureus - pathogenicity ; Staphylococcus infections ; Superantigens ; Surface antigens ; Toxins ; Vaccination ; Vaccines ; Virulence ; Virulence factors ; Virulence Factors - genetics ; Virulence Factors - immunology
É parte de: FEMS microbiology reviews, 2020-01, Vol.44 (1), p.123-153
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: ABSTRACT Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in both hospital and community settings, especially with the widespread emergence of virulent and multi-drug resistant methicillin-resistant S. aureus strains. There is an urgent and unmet clinical need for non-antibiotic immune-based approaches to treat these infections as the increasing antibiotic resistance is creating a serious threat to public health. However, all vaccination attempts aimed at preventing S. aureus invasive infections have failed in human trials, especially all vaccines aimed at generating high titers of opsonic antibodies against S. aureus surface antigens to facilitate antibody-mediated bacterial clearance. In this review, we summarize the data from humans regarding the immune responses that protect against invasive S. aureus infections as well as host genetic factors and bacterial evasion mechanisms, which are important to consider for the future development of effective and successful vaccines and immunotherapies against invasive S. aureus infections in humans. The evidence presented form the basis for a hypothesis that staphylococcal toxins (including superantigens and pore-forming toxins) are important virulence factors, and targeting the neutralization of these toxins are more likely to provide a therapeutic benefit in contrast to prior vaccine attempts to generate antibodies to facilitate opsonophagocytosis. This review summarizes the data from humans regarding the immune responses that protect against invasive Staphylococcus aureus infections as well as host genetic factors and bacterial evasion mechanisms, which form the basis for a hypothesis that future vaccines and immune-based therapies that target the neutralization of staphylococcal toxins superantigens and pore-forming toxins are more likely to provide a therapeutic benefit.
Editor: England: Oxford University Press
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms

Miller, Lloyd S ; Fowler, Vance G ; Shukla, Sanjay K ; Rose, Warren E ; Proctor, Richard A

England: Oxford University Press

Buscando em bases de dados remotas. Favor aguardar.