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Antifungal peptides: To be or not to be membrane active

Rautenbach, Marina ; Troskie, Anscha M. ; Vosloo, J. Arnold

Biochimie, 2016-11, Vol.130, p.132-145 [Periódico revisado por pares]

France: Elsevier B.V

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Título:
Antifungal peptides: To be or not to be membrane active
Autor: Rautenbach, Marina ; Troskie, Anscha M. ; Vosloo, J. Arnold
Assuntos: Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antifungal peptides ; beta-Glucans - chemistry ; beta-Glucans - metabolism ; Cell membrane ; Cell Membrane - chemistry ; Cell Membrane - drug effects ; Cell Membrane - metabolism ; Cell Membrane Permeability - drug effects ; Cell wall ; Cell Wall - chemistry ; Cell Wall - drug effects ; Cell Wall - metabolism ; Fungi - chemistry ; Fungi - drug effects ; Fungi - metabolism ; Membrane lipids ; Membrane Lipids - chemistry ; Membrane Lipids - metabolism ; Mode of action ; Models, Biological ; Molecular Structure ; Peptides - chemistry ; Peptides - pharmacology
É parte de: Biochimie, 2016-11, Vol.130, p.132-145
Descrição: Most antifungal peptides (AFPs), if not all, have membrane activity, while some also have alternative targets. Fungal membranes share many characteristics with mammalian membranes with only a few differences, such as differences in sphingolipids, phosphatidylinositol (PI) content and the main sterol is ergosterol. Fungal membranes are also more negative and a better target for cationic AFPs. Targeting just the fungal membrane lipids such as phosphatidylinositol and/or ergosterol by AFPs often translates into mammalian cell toxicity. Conversely, a specific AFP target in the fungal pathogen, such as glucosylceramide, mannosyldiinositol phosphorylceramide or a fungal protein target translates into high pathogen selectivity. However, a lower target concentration, absence or change in the specific fungal target can naturally lead to resistance, although such resistance in turn could result in reduced pathogen virulence. The question is then to be or not to be membrane active - what is the best choice for a successful AFP? In this review we deliberate on this question by focusing on the recent advances in our knowledge on how natural AFPs target fungi. •Is membrane activity the best option for antifungal peptides (AFPs)?•Fungal membranes have unique lipids that are targeted by AFPs.•Targeting just fungal membrane lipids can translate into mammalian cell toxicity.•If an AFP only has one specific fungal target there is some potential for resistance.•Many AFPs target the fungal membrane, as well as other fungal components/systems.
Editor: France: Elsevier B.V
Idioma: Inglês

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Antifungal peptides: To be or not to be membrane active

Rautenbach, Marina ; Troskie, Anscha M. ; Vosloo, J. Arnold

France: Elsevier B.V

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