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Fontan-associated liver disease current status and transplantation consideration

Liu, X ; Tu, J Z C ; Teng, Y ; Chen, J M

Zhonghua gan zang bing za zhi, 2023-01, Vol.31 (1), p.109

China

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Título:
Fontan-associated liver disease current status and transplantation consideration
Autor: Liu, X ; Tu, J Z C ; Teng, Y ; Chen, J M
Assuntos: Carcinoma, Hepatocellular - pathology ; Fontan Procedure - adverse effects ; Humans ; Liver - pathology ; Liver Cirrhosis - pathology ; Liver Diseases - pathology ; Liver Neoplasms - pathology ; Liver Transplantation - adverse effects ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Postoperative Complications - pathology
É parte de: Zhonghua gan zang bing za zhi, 2023-01, Vol.31 (1), p.109
Descrição: Fontan-associated liver disease (FALD) is one of the main complications after the Fontan procedure, manifesting mostly as liver fibrosis and even cirrhosis, with a high incidence rate and a lack of typical clinical symptoms that seriously affect patient prognosis. The specific cause is unknown, although it is considered to be associated with long-term elevated central venous pressure, impaired hepatic artery blood flow, and other relevant factors. The absence of association between laboratory tests, imaging data, and the severity of liver fibrosis makes clinical diagnosis and monitoring difficult. A liver biopsy is the gold standard for diagnosing and staging liver fibrosis. The most important risk factor for FALD is time following the Fontan procedure; therefore, it is recommended to do a liver biopsy 10 years after the Fontan procedure and to be cautious for the presence of hepatocellular carcinoma. Combined heart-liver transplantation is a recommended choice with favorable outcomes for patients with Fontan
Editor: China
Idioma: Chinês

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Fontan-associated liver disease current status and transplantation consideration

Liu, X ; Tu, J Z C ; Teng, Y ; Chen, J M

China

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