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Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics

Kazdoba, Tatiana M. ; Leach, Prescott T. ; Yang, Mu ; Silverman, Jill L. ; Solomon, Marjorie ; Crawley, Jacqueline N.

Current topics in behavioral neurosciences, 2016, Vol.28, p.1-52 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics
Autor: Kazdoba, Tatiana M. ; Leach, Prescott T. ; Yang, Mu ; Silverman, Jill L. ; Solomon, Marjorie ; Crawley, Jacqueline N.
Assuntos: Animals ; Autism ; Autistic Disorder - drug therapy ; Autistic Disorder - genetics ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Clinical trials ; Cognition ; Construct validity ; Disease Models, Animal ; Face validity ; Genes ; Mice ; Mice, Knockout ; Mouse ; Mutant models ; Pharmacological treatment ; Phenotype ; Preclinical ; Predictive validity ; Rats ; Repetitive behavior ; Sociability ; Social Behavior ; Translational ; Translational Medical Research ; Ultrasonic vocalization
É parte de: Current topics in behavioral neurosciences, 2016, Vol.28, p.1-52
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Animal models provide preclinical tools to investigate the causal role of genetic mutations and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and humanized knock-in mice, and more recently knockout rats, have been generated for many of the de novo single gene mutations and copy number variants (CNVs) detected in ASD and comorbid neurodevelopmental disorders. Mouse models incorporating genetic and environmental manipulations have been employed for preclinical testing of hypothesis-driven pharmacological targets, to begin to develop treatments for the diagnostic and associated symptoms of autism. In this review, we summarize rodent behavioral assays relevant to the core features of autism, preclinical and clinical evaluations of pharmacological interventions, and strategies to improve the translational value of rodent models of autism.
Títulos relacionados: Current Topics in Behavioral Neurosciences
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics

Kazdoba, Tatiana M. ; Leach, Prescott T. ; Yang, Mu ; Silverman, Jill L. ; Solomon, Marjorie ; Crawley, Jacqueline N.

Cham: Springer International Publishing

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