Idioma:

Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis

Martin, Gabriel V ; Kanaan, Sami B ; Hemon, Marie F ; Azzouz, Doua F ; El Haddad, Marina ; Balandraud, Nathalie ; Mignon-Ravix, Cécile ; Picard, Christophe ; Arnoux, Fanny ; Martin, Marielle ; Roudier, Jean ; Auger, Isabelle ; Lambert, Nathalie C

Scientific reports, 2019-09, Vol.9 (1), p.12880-11, Article 12880 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis
Autor: Martin, Gabriel V ; Kanaan, Sami B ; Hemon, Marie F ; Azzouz, Doua F ; El Haddad, Marina ; Balandraud, Nathalie ; Mignon-Ravix, Cécile ; Picard, Christophe ; Arnoux, Fanny ; Martin, Marielle ; Roudier, Jean ; Auger, Isabelle ; Lambert, Nathalie C
Assuntos: Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - genetics ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Autoimmune diseases ; Case-Control Studies ; Chromosomes, Human, X - genetics ; Chromosomes, Human, Y - genetics ; Copy number ; Fluorescence in situ hybridization ; Gene Dosage ; Genes ; Genetics ; Human genetics ; Human health and pathology ; Humans ; Hybridization ; Immunology ; Inflammation ; Life Sciences ; Male ; Menopause ; Mosaicism ; Peripheral blood ; Rheumatoid arthritis ; Rhumatology and musculoskeletal system ; RNA, Messenger - genetics ; Signal Transduction ; TLR7 protein ; Toll-Like Receptor 7 - genetics ; Toll-Like Receptor 7 - metabolism ; Toll-Like Receptor 8 - genetics ; Toll-Like Receptor 8 - metabolism ; Toll-like receptors ; X Chromosomes
É parte de: Scientific reports, 2019-09, Vol.9 (1), p.12880-11, Article 12880
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The X chromosome, hemizygous in males, contains numerous genes important to immunological and hormonal function. Alterations in X-linked gene dosage are suspected to contribute to female predominance in autoimmunity. A powerful example of X-linked dosage involvement comes from the BXSB murine lupus model, where the duplication of the X-linked Toll-Like Receptor 7 (Tlr7) gene aggravates autoimmunity in male mice. Such alterations are possible in men with autoimmune diseases. Here we showed that a quarter to a third of men with rheumatoid arthritis (RA) had significantly increased copy numbers (CN) of TLR7 gene and its paralog TLR8. Patients with high CN had an upregulated pro-inflammatory JNK/p38 signaling pathway. By fluorescence in situ hybridization, we further demonstrated that the increase in X-linked genes CN was due to the presence of an extra X chromosome in some cells. Men with RA had a significant cellular mosaicism of female (46,XX) and/or Klinefelter (47,XXY) cells among male (46,XY) cells, reaching up to 1.4% in peripheral blood. Our results present a new potential trigger for RA in men and opens a new field of investigation particularly relevant for gender-biased autoimmune diseases.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis

Martin, Gabriel V ; Kanaan, Sami B ; Hemon, Marie F ; Azzouz, Doua F ; El Haddad, Marina ; Balandraud, Nathalie ; Mignon-Ravix, Cécile ; Picard, Christophe ; Arnoux, Fanny ; Martin, Marielle ; Roudier, Jean ; Auger, Isabelle ; Lambert, Nathalie C

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.