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Acute Basilar Artery Occlusion in the Basilar Artery International Cooperation Study Does Gender Matter?

ARNOLD, Marcel ; FISCHER, Urs ; COMPTER, Annette ; GRALLA, Jan ; FINDLING, Oliver ; MATTLE, Heinrich P ; KAPPELLE, L. Jaap ; TANNE, David ; ALGRA, Ale ; SCHONEWILLE, Wouter J

Stroke (1970), 2010-11, Vol.41 (11), p.2693-2696 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Acute Basilar Artery Occlusion in the Basilar Artery International Cooperation Study Does Gender Matter?
Autor: ARNOLD, Marcel ; FISCHER, Urs ; COMPTER, Annette ; GRALLA, Jan ; FINDLING, Oliver ; MATTLE, Heinrich P ; KAPPELLE, L. Jaap ; TANNE, David ; ALGRA, Ale ; SCHONEWILLE, Wouter J
Assuntos: Aged ; Aged, 80 and over ; Biological and medical sciences ; Cardiovascular system ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Female ; Fibrinolytic Agents - administration & dosage ; Fibrinolytic Agents - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Humans ; Injections, Intra-Arterial ; Injections, Intravenous ; Male ; Medical sciences ; Middle Aged ; Neurology ; Neurosurgery ; Pharmacology. Drug treatments ; Registries ; Sex Characteristics ; Skull, brain, vascular surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Survival Rate ; Thrombolytic Therapy ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system ; Vasodilator agents. Cerebral vasodilators ; Vertebrates: nervous system and sense organs ; Vertebrobasilar Insufficiency - drug therapy ; Vertebrobasilar Insufficiency - mortality
É parte de: Stroke (1970), 2010-11, Vol.41 (11), p.2693-2696
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Descrição: Randomized trials suggested a different benefit of intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) between men and women with anterior circulation stroke because of a worse outcome of women in the control group. We compared outcome and recanalization in men and women with basilar artery occlusion treated with antithrombotic treatment alone, IVT or combined IVT-IAT, or IAT in the Basilar Artery International Cooperation Study. Overall, 389 male and 226 female patients were analyzed. In the antithrombotic treatment group, 68 of 111 (61%) men and 47 of 70 (67%) women had a poor outcome defined as a modified Rankin Scale score of 4 to 6 (adjusted risk ratio [aRR], 0.96; 95% CI, 0.75 to 1.24), in the IVT/combined IVT-IAT group, 47 of 77 (61%) men and 24 of 43 (56%) women (aRR, 1.19; 95% CI, 0.89 to 1.60), and in the IAT group, 142 of 185 (77%) men and 71 of 102 (70%) women (aRR, 1.01; 95% CI, 0.88 to 1.17). Mortality was not different between men and women in the antithrombotic treatment group (aRR, 0.80; 95% CI, 0.55 to 1.16), the IVT/combined IVT-IAT group (aRR, 1.11; 95% CI, 0.72 to 1.73), or in the IAT group (aRR, 1.01; 95% CI, 0.75 to 1.36). Insufficient recanalization after combined IVT-IAT or IAT was similar in men and women (23% versus 22%; aRR, 0.92; 95% CI, 0.58 to 1.46). In patients with acute basilar artery occlusion, no significant gender differences for outcome and recanalization were observed, regardless of treatment modality.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Acute Basilar Artery Occlusion in the Basilar Artery International Cooperation Study Does Gender Matter?

ARNOLD, Marcel ; FISCHER, Urs ; COMPTER, Annette ; GRALLA, Jan ; FINDLING, Oliver ; MATTLE, Heinrich P ; KAPPELLE, L. Jaap ; TANNE, David ; ALGRA, Ale ; SCHONEWILLE, Wouter J

Hagerstown, MD: Lippincott Williams & Wilkins

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