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Cognitive effects of nicotine in humans: an fMRI study

Kumari, Veena ; Gray, Jeffrey A ; ffytche, Dominic H ; Mitterschiffthaler, Martina T ; Das, Mrigen ; Zachariah, Elizabeth ; Vythelingum, Goparlen N ; Williams, Steven C.R ; Simmons, Andrew ; Sharma, Tonmoy

NeuroImage (Orlando, Fla.), 2003-07, Vol.19 (3), p.1002-1013 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Cognitive effects of nicotine in humans: an fMRI study
Autor: Kumari, Veena ; Gray, Jeffrey A ; ffytche, Dominic H ; Mitterschiffthaler, Martina T ; Das, Mrigen ; Zachariah, Elizabeth ; Vythelingum, Goparlen N ; Williams, Steven C.R ; Simmons, Andrew ; Sharma, Tonmoy
Assuntos: Adult ; Algorithms ; Analysis of Variance ; Animal cognition ; Anterior cingulate ; Attention ; Brain ; Brain - physiology ; Cerebellum ; Cognitive effects ; Female ; Functional magnetic resonance imaging ; Humans ; Image Processing, Computer-Assisted - statistics & numerical data ; Imagination - physiology ; Ligands ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Medical screening ; Memory ; Memory - physiology ; Neural network ; Neural networks ; Nicotine ; Older people ; Oxygen - blood ; Parahippocampal gyrus ; Rodents ; Smoking ; Studies ; Working memory
É parte de: NeuroImage (Orlando, Fla.), 2003-07, Vol.19 (3), p.1002-1013
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-News-3
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Descrição: To elucidate the neural correlates of cognitive effects of nicotine, we examined behavioral performance and blood oxygenation level-dependent regional brain activity, using functional magnetic resonance imaging, during a parametric “n-back” task in healthy nonsmoking males after the administration of nicotine (12 μg/kg body weight) or saline. Nicotine, compared to placebo, improved accuracy ( P = 0.008) in all active conditions (2%–11%), and had a load-specific effect on latency ( P = 0.004; 43.78% decrease at the highest memory load). Within a network of parietal and frontal areas activated by the task ( P < 0.05, corrected at the voxel level), nicotine produced an increased response ( P < 0.05; uncorrected within the regions of interest) in the anterior cingulate, superior frontal cortex, and superior parietal cortex. It also produced an increased response in the midbrain tectum in all active conditions and in the parahippocampal gyrus, cerebellum, and medial occipital lobe during rest ( P = 0.05; uncorrected). The present observations point to altered neuronal activity in a distributed neural network associated with on-line task monitoring and attention and arousal systems as underlying nicotine-related enhancement of attention and working memory in human subjects.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Cognitive effects of nicotine in humans: an fMRI study

Kumari, Veena ; Gray, Jeffrey A ; ffytche, Dominic H ; Mitterschiffthaler, Martina T ; Das, Mrigen ; Zachariah, Elizabeth ; Vythelingum, Goparlen N ; Williams, Steven C.R ; Simmons, Andrew ; Sharma, Tonmoy

United States: Elsevier Inc

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