skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Chromatin: a tunable spring at work inside chromosomes

Ben-Haïm, E ; Lesne, A ; Victor, J M

Physical review. E, 2001-11, Vol.64 (5 Pt 1), p.051921-051921, Article 051921 [Periódico revisado por pares]

United States: American Physical Society (APS)

Texto completo disponível

Citações Citado por
  • Título:
    Chromatin: a tunable spring at work inside chromosomes
  • Autor: Ben-Haïm, E ; Lesne, A ; Victor, J M
  • Assuntos: Biochemistry, Molecular Biology ; Biomechanical Phenomena ; Biophysical Phenomena ; Biophysics ; Chromatin - chemistry ; Chromosomes - chemistry ; Condensed Matter ; DNA - chemistry ; Elasticity ; Histones - chemistry ; Life Sciences ; Models, Biological ; Molecular Conformation ; Nucleosomes - chemistry ; Physics ; Statistical Mechanics
  • É parte de: Physical review. E, 2001-11, Vol.64 (5 Pt 1), p.051921-051921, Article 051921
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: This paper focuses on mechanical aspects of chromatin biological functioning. Within a basic geometric modeling of the chromatin assembly, we give a complete set of elastic constants (twist and bend persistence lengths, stretch modulus and twist-stretch coupling constant) of the so-called 30-nm chromatin fiber, in terms of DNA elastic properties and geometric properties of the fiber assembly. The computation naturally embeds the fiber within a current analytical model known as the "extensible wormlike rope," allowing a straightforward prediction of the force-extension curves. We show that these elastic constants are strongly sensitive to the linker length, up to 1 bp, or equivalently to its twist, and might locally reach very low values, yielding a highly flexible and extensible domain in the fiber. In particular, the twist-stretch coupling constant, reflecting the chirality of the chromatin fiber, exhibits steep variations, and sign changes when the linker length is varied. We argue that this tunable elasticity might be a key feature for chromatin function, for instance, in the initiation and regulation of transcription.
  • Editor: United States: American Physical Society (APS)
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.