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LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing

Le Douce, Valentin ; Colin, Laurence ; Redel, Laetitia ; Cherrier, Thomas ; Herbein, Georges ; Aunis, Dominique ; Rohr, Olivier ; Van Lint, Carine ; Schwartz, Christian

Nucleic acids research, 2012-03, Vol.40 (5), p.1904-1915 [Periódico revisado por pares]

England: Oxford University Press

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Título:
LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing
Autor: Le Douce, Valentin ; Colin, Laurence ; Redel, Laetitia ; Cherrier, Thomas ; Herbein, Georges ; Aunis, Dominique ; Rohr, Olivier ; Van Lint, Carine ; Schwartz, Christian
Assuntos: Biochemistry, biophysics & molecular biology ; Biochimie, biophysique & biologie moléculaire ; Cell Line ; Cell Nucleus - chemistry ; Cell Nucleus - virology ; Cell Nucleus/chemistry/virology ; Cellular Biology ; Central nervous system ; Chromatin ; Cofactors ; Data processing ; Epigenesis, Genetic ; epigenetics ; Gene Regulation, Chromatin and Epigenetics ; Gene Silencing ; Heterochromatin ; Histone deacetylase ; Histone Demethylases - analysis ; Histone Demethylases - metabolism ; Histone Demethylases/analysis/metabolism ; Histone-Lysine N-Methyltransferase - metabolism ; Histones ; Histones - metabolism ; HIV Long Terminal Repeat ; HIV-1 - genetics ; HIV-1 - physiology ; HIV-1/genetics/physiology ; Human immunodeficiency virus 1 ; Humans ; Latent infection ; Life Sciences ; Methylation ; Microglia - virology ; Microglial cells ; Promoter Regions, Genetic ; Promoters ; Proviruses ; Repressor Proteins - analysis ; Repressor Proteins - metabolism ; Repressor Proteins/analysis/metabolism ; Sciences du vivant ; tat Gene Products, Human Immunodeficiency Virus - analysis ; Transcription ; Transcription, Genetic ; Tumor Suppressor Proteins - analysis ; Tumor Suppressor Proteins - metabolism ; Tumor Suppressor Proteins/analysis/metabolism ; Virus Replication
É parte de: Nucleic acids research, 2012-03, Vol.40 (5), p.1904-1915
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
Descrição: Microglial cells are the main HIV-1 targets in the central nervous system (CNS) and constitute an important reservoir of latently infected cells. Establishment and persistence of these reservoirs rely on the chromatin structure of the integrated proviruses. We have previously demonstrated that the cellular cofactor CTIP2 forces heterochromatin formation and HIV-1 gene silencing by recruiting HDAC and HMT activities at the integrated viral promoter. In the present work, we report that the histone demethylase LSD1 represses HIV-1 transcription and viral expression in a synergistic manner with CTIP2. We show that recruitment of LSD1 at the HIV-1 proximal promoter is associated with both H3K4me3 and H3K9me3 epigenetic marks. Finally, our data suggest that LSD1-induced H3K4 trimethylation is linked to hSET1 recruitment at the integrated provirus.
Editor: England: Oxford University Press
Idioma: Inglês;Francês

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LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing

Le Douce, Valentin ; Colin, Laurence ; Redel, Laetitia ; Cherrier, Thomas ; Herbein, Georges ; Aunis, Dominique ; Rohr, Olivier ; Van Lint, Carine ; Schwartz, Christian

England: Oxford University Press

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