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Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals

SAAD, Ahmed ; MAN, Chiara Dalla ; BASU, Ananda ; NANDY, Debashis K ; LEVINE, James A ; BHARUCHA, Adil E ; RIZZA, Robert A ; BASU, Rita ; CARTER, Rickey E ; COBELLI, Claudio ; KUDVA, Yogish C

Diabetes (New York, N.Y.), 2012-11, Vol.61 (11), p.2691-2700 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals
Autor: SAAD, Ahmed ; MAN, Chiara Dalla ; BASU, Ananda ; NANDY, Debashis K ; LEVINE, James A ; BHARUCHA, Adil E ; RIZZA, Robert A ; BASU, Rita ; CARTER, Rickey E ; COBELLI, Claudio ; KUDVA, Yogish C
Assuntos: Adolescent ; Adult ; Analysis ; Biological and medical sciences ; Blood glucose ; Blood Glucose - analysis ; Blood sugar ; Carbon Isotopes ; Circadian Rhythm ; Circadian rhythms ; Cohort Studies ; Cross-Over Studies ; Deuterium ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gluconeogenesis ; Glucose - metabolism ; Glucose Intolerance - blood ; Glucose Intolerance - metabolism ; Humans ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; Insulin-Secreting Cells - metabolism ; Male ; Medical sciences ; Metabolism ; Middle Aged ; Postprandial Period ; Young Adult
É parte de: Diabetes (New York, N.Y.), 2012-11, Vol.61 (11), p.2691-2700
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
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A.S., C.D.M., and D.K.N. contributed equally to this study.
Descrição: Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is important to inform a closed-loop system of treatment for insulin requiring diabetes. We studied 20 healthy volunteers with normal fasting glucose (4.8 ± 0.1 mmol/L) and HbA(1c) (5.2 ± 0.0%) to determine such a pattern in nondiabetic individuals. Identical mixed meals were ingested during breakfast, lunch, or dinner at 0700, 1300, and 1900 h in randomized Latin square order on 3 consecutive days. Physical activity was the same on all days. Postprandial glucose turnover was measured using the triple tracer technique. Postprandial glucose excursion was significantly lower (P < 0.01) at breakfast than lunch and dinner. β-Cell responsivity to glucose and disposition index was higher (P < 0.01) at breakfast than lunch and dinner. Hepatic insulin extraction was lower (P < 0.01) at breakfast than dinner. Although meal glucose appearance did not differ between meals, suppression of endogenous glucose production tended to be lower (P < 0.01) and insulin sensitivity tended to be higher (P < 0.01) at breakfast than at lunch or dinner. Our results suggest a diurnal pattern to glucose tolerance in healthy humans, and if present in type 1 diabetes, it will need to be incorporated into artificial pancreas systems.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals

SAAD, Ahmed ; MAN, Chiara Dalla ; BASU, Ananda ; NANDY, Debashis K ; LEVINE, James A ; BHARUCHA, Adil E ; RIZZA, Robert A ; BASU, Rita ; CARTER, Rickey E ; COBELLI, Claudio ; KUDVA, Yogish C

Alexandria, VA: American Diabetes Association

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