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Pulmonary Effects of Indoor- and Outdoor-Generated Particles in Children with Asthma

Koenig, Jane Q. ; Mar, Therese F. ; Allen, Ryan W. ; Jansen, Karen ; Lumley, Thomas ; Sullivan, Jeffrey H. ; Trenga, Carol A. ; Larson, Timothy V. ; L.-Jane S. Liu

Environmental health perspectives, 2005-04, Vol.113 (4), p.499-503 [Periódico revisado por pares]

United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare

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  • Título:
    Pulmonary Effects of Indoor- and Outdoor-Generated Particles in Children with Asthma
  • Autor: Koenig, Jane Q. ; Mar, Therese F. ; Allen, Ryan W. ; Jansen, Karen ; Lumley, Thomas ; Sullivan, Jeffrey H. ; Trenga, Carol A. ; Larson, Timothy V. ; L.-Jane S. Liu
  • Assuntos: Adolescent ; Adrenal Cortex Hormones ; Air Pollutants - adverse effects ; Air Pollutants - analysis ; Air pollution ; Air Pollution, Indoor - adverse effects ; Air Pollution, Indoor - analysis ; Asthma ; Asthma - epidemiology ; Child ; Children ; Children's Health ; Cohort Studies ; Dust - analysis ; Health benefits ; Housing ; Humans ; Inhalation Exposure ; Lungs ; Modeling ; Models, Theoretical ; Nitric Oxide - analysis ; Oxides ; Particle Size ; Particulate matter ; Predictive modeling ; Spirometry ; Washington - epidemiology
  • É parte de: Environmental health perspectives, 2005-04, Vol.113 (4), p.499-503
  • Notas: ObjectType-Article-2
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    The authors declare they have no competing financial interests.
    We thank L. Tuttle, T. Gould, M. Drudge, and the field/lab technicians who worked on this project. We owe a great deal to our study subjects.
    This work was funded by the U.S. Environmental Protection Agency (EPA; CR82717701), the Northwest Research Center for Particulate Air Pollution and Health (U.S. EPA grant CR827355), and National Institute of Environmental Health Sciences grant P30 ES07033. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use.
  • Descrição: Most particulate matter (PM) health effects studies use outdoor (ambient) PM as a surrogate for personal exposure. However, people spend most of their time indoors exposed to a combination of indoor-generated particles and ambient particles that have infiltrated. Thus, it is important to investigate the differential health effects of indoor- and ambient-generated particles. We combined our recently adapted recursive model and a predictive model for estimating infiltration efficiency to separate personal exposure (E) to PM2.5(PM with aerodynamic diameter ≤ 2.5 μm) into its indoor-generated (Eig) and ambient-generated (Eag) components for 19 children with asthma. We then compared Eigand Eagto changes in exhaled nitric oxide (eNO), a marker of airway inflammation. Based on the recursive model with a sample size of eight children, Eagwas marginally associated with increases in eNO [5.6 ppb per 10-μ g/ m3increase in PM2.5; 95% confidence interval (CI), -0.6 to 11.9; p = 0.08]. Eigwas not associated with eNO (-0.19 ppb change per 10 μ g/ m3). Our predictive model allowed us to estimate Eagand Eigfor all 19 children. For those combined estimates, only Eagwas significantly associated with an increase in eNO (Eag: 5.0 ppb per 10-μ g/ m3increase in PM2.5; 95% CI, 0.3 to 9.7; p = 0.04; Eig: 3.3 ppb per 10-μ g/ m3increase in PM2.5; 95% CI, -1.1 to 7.7; p = 0.15). Effects were seen only in children who were not using corticosteroid therapy. We conclude that the ambient-generated component of PM2.5exposure is consistently associated with increases in eNO and the indoor-generated component is less strongly associated with eNO.
  • Editor: United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare
  • Idioma: Inglês
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