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Experimental studies of the role of the little raven (Corvus mellori) in surveillance for West Nile virus in Australia

Bingham, J ; Lunt, R.A ; Green, D.J ; Davies, K.R ; Stevens, V ; Wong, F.Y.K

Australian veterinary journal, 2010-06, Vol.88 (6), p.204-210 [Periódico revisado por pares]

Melbourne, Australia: Blackwell Publishing Asia

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Título:
Experimental studies of the role of the little raven (Corvus mellori) in surveillance for West Nile virus in Australia
Autor: Bingham, J ; Lunt, R.A ; Green, D.J ; Davies, K.R ; Stevens, V ; Wong, F.Y.K
Assuntos: animal ovaries ; Animals ; Antibodies, Viral - blood ; antigens ; Antigens, Viral - analysis ; Australasia ; Australia ; Bird Diseases - immunology ; Bird Diseases - virology ; blood ; Corvus ; Corvus mellori ; Crows ; histopathology ; hosts ; immunohistochemistry ; kidneys ; Kunjin virus ; little raven ; liver ; Mice ; monitoring ; Reverse Transcriptase Polymerase Chain Reaction - veterinary ; RNA, Viral - chemistry ; RNA, Viral - genetics ; Sentinel Surveillance - veterinary ; spleen ; testes ; viremia ; Virulence ; viruses ; West Nile Fever - immunology ; West Nile Fever - transmission ; West Nile Fever - veterinary ; West Nile Fever - virology ; West Nile virus ; West Nile virus - genetics ; West Nile virus - immunology
É parte de: Australian veterinary journal, 2010-06, Vol.88 (6), p.204-210
Notas: http://www.ava.com.au/avjpast.php?journalid=9&plink=avj03.htm
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Descrição: Keywords:Australia;Corvus mellori;Kunjin virus;little raven;West Nile virus Objective To study the potential role of an Australian corvid, the little raven (Corvus mellori), in the surveillance for exotic West Nile virus (WNV) in Australia. Method In a series of trials, little ravens were infected with WNV (strain 4132 New York 1999) and Kunjin virus (strain K42886) by the intramuscular route. They were observed for 20 days during which blood and swab samples were taken for virus isolation. Tissue samples were taken from ravens humanely killed during the acute infection period, and at the termination of the trials, for virus isolation, histopathology and immunohistochemistry. Results Ravens infected with WNV became mildly ill, but all recovered and seroconverted. Blood virus titres peaked around 3 to 4 days after inoculation at levels between 103.0 to 107.5 plaque forming units/mL. Virus or viral antigen was detected in spleen, liver, lung, kidney, intestine, testis and ovary by virus isolation and/or immunohistochemistry. WNV was detected in oral and cloacal swabs from 2 to 7 days post inoculation. The molecular and pathogenic characteristics of the inocula were consistent with them being of high virulence, as expected for this isolate. Ravens infected with Kunjin virus developed viraemia and seroconverted, although they did not develop disease. Conclusions Little ravens do not develop severe disease in response to virulent WNV infection and for this reason may not be important sentinel hosts in the event of an outbreak of WNV, as in North America. However, as they have relatively high viraemias, they may be able to support virus cycles.
Editor: Melbourne, Australia: Blackwell Publishing Asia
Idioma: Inglês

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Experimental studies of the role of the little raven (Corvus mellori) in surveillance for West Nile virus in Australia

Bingham, J ; Lunt, R.A ; Green, D.J ; Davies, K.R ; Stevens, V ; Wong, F.Y.K

Melbourne, Australia: Blackwell Publishing Asia

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